The fact that fluctuations of refractivity may result in a systematic negative shift of the phase of waves propagating in a random medium is known for a long time. Tatarskii was the first to reveal it, and von Eshleman put this into the context of the radio occultation sounding of planetary atmospheres. In this paper, we show that this effect may also be one of the causes of the negative bias of refractivity retrieved for radio occultation observations of the Earth's atmosphere. We perform theoretical estimates of this effect based on the Rytov approximation. These estimates, however, do not consider the regular refraction, which may significantly change the magnitude of this effect. We perform numerical simulations of radio occultations, based on the Kolmogorov-von Kármán isotropic spectrum of refractivity fluctuations, with the internal and external scales and magnitude tuned so as to reproduce the realistic level of the variance of retrieved refractivity and the amplitude fluctuations of the modeled signals. The model of the regular atmosphere is based on analyses of the European Centre for Medium-Range Weather Forecasts. We show that it is possible to set up a vertical profile of the structural constant of the fluctuation spectrum such that it will result in a systematic shift and variances of the retrieved refractivity consistent with those observed for COSMIC measurements.

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Intracerebroventricular administration of the peptides kyotorphin (Tyr-Arg), neokyotorphin (Thr-Ser-Lys-Tyr-Arg), and Asp-Tyr at doses of 4 and 8 micrograms altered the behavior of rats in a manner similar to that seen after similar administration of brain fractions from hibernating ground squirrels (Citellus undulatus), which contained these peptides; there were increases in orientational reactions, increases in the frequency of stereotypical scratching movements, grooming, yawning, hiccuping, and sneezing. Animals became drowsy after 15-20 min. Peptides and brain fractions also had similar effects on the EEG of rats. Brain fractions reduced theta and alpha rhythms and enhanced delta and beta frequencies. Increases in delta waves were seen with all peptides (a 4-microgram dose of kyotorphin produced alternating increases and reductions in the delta rhythm). Inhibition of theta and alpha rhythms after administration of Asp-Tyr and kyotorphin was more transient than after brain fractions. Increases in beta frequencies were seen only after administration of 8 micrograms of Asp-Tyr, the smaller dose not producing this effect.

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