The author made an organizational and legal, clinical and pharmacological study of the latest International Classification of Diseases (ICD-11) concerning its changes compared to the ICD-10. Particular attention was paid to new ways of marking of disease codes and new functions of the ICD-11. Novel structure based on cluster coding, which was implemented into the new revision was mentioned, which allows to connect the main diagnostic codes with advanced clinical indicators. Author found that for the first time, the new revision has become a fully electronic publication that provides access to more than 17,000 diagnostic categories that contain more than hundred thousand of terms of the medical diagnostic index. The new ICD-11 concept of linearization for the national needs of each country was taken into account, which will save budget expenditures for the future. In the new edition of the ICD-11, for the first time, gambling addiction is classified as a mental disorder – behavioral addiction to online and offline gambling. The list of ICD-11 short stories also includes the classification of the following: chronic pain, burnout, stroke, sexual health, post-traumatic stress disorder, allergies, alternative medicine, etc. It is a more powerful health information system based on a formal ontology, designed to integrate information technology into modern infrastructures. A comparison with the ICD-10 on mental and behavioral disorders due to the use of psychoactive substances was made. The ICD-11 has been identified as having a more comprehensive list of disease diagnosis codes, and in the ICD-10 the section on mental and behavioral disorders due to substance use has eleven core codes. Indicated the prospects of using of the ICD-11 in medical practice.
Introduction. Modern turbulent state of society actualizes need for scientifically based methods and technological solutions to improve the information security system not only for the state, but also for society and the person in particular. Objective. To highlight the significant factors of information security of social development and to study the role of public admini-stration in the context of the actualization of information threats and risks. Study results. The article considers the essence of state management approaches to information security based on interpretation in terms of risk management. Information security is presented as a dynamic system that needs balance. Balance can be disturbed by external and internal factors. The 8 most significant factors that need to be taken into account to develop effective models of public administration in the field of information security are identified. 4 paradigms of information security management (systemic, synergetic, phenomenological and cognitive) which can be involved are considered. However, they are not universal and separate in any particular case, that is they are systemic in nature, and security management should be based on their integrated application depending on the situation and the specifics of the management process. Based on the analysis of the classical model of maintaining the state balance of a dynamic system, it is concluded that it can be used to ensure information security. A model is proposed to explain the reasons for the imbalance of the dynamic system of information security under the action of factors of influence and the risks that accompany them, and to determine the measures of public administration to ensure it. Conclusion. The model is proposed to explain the reasons for the imbalance of the dynamic system of information security under the action of factors of influence and the risks that accompany them, and to determine the measures of public administration to ensure it. Key words: Information security; Information security factors; Society; Public administration; Information security model.
The article presents the results of the research for the new challenges of today regarding the incidence of monkeypox virus using organizational and legal, clinical and pharmacological approaches to analyze epidemiology, risks, symptoms, vaccination opportunities, recommendations for detection, pharmacotherapy and prevention. Complex experimental organizational and legal, clinical a n d pharmacological study was conducted. The research was conducted on the basis of the disciplines of healthcare organization, pharmacy organization and management, forensic pharmacy, clinical pharmacy, management for different groups of patients and was based on the principles of evidence-based medicine, evidence-based pharmacy. Issues of epidemiology, risks, symptoms, vaccination of monkeypox disease were studied. Recommendations of the WHO and scientific circles concerning the effectiveness of detection, pharmacotherapy, and prevention of monkeypox were analyzed.
The COVID-19 pandemic has strained the healthcare system. It is important to consider forensic and pharmaceutical risks in the organization of vaccination practices and pharmacotherapy of covid, post-covid and long-covid disorders. Scientific sources on the clinical characteristics of SARS-CoV-2, COVID-19 have been systematized. The standards of vaccination practice (immunization, vaccination) of different age categories of the population in Ukraine, England, USA, Belgium, Greece, Japan, and Portugal were analyzed. Proven that the organization of pharmacotherapy schemes is difficult due to the presence of mixed infections, comorbid and complicated forms of diseases, the formation of virus resistance to drugs, and the development of secondary immunological insufficiency. The risks of pharmacotherapy with regard to mortality in patients with COVID-19 due to the development of severe lung lesions and systemic multiorgan pathology are indicated. Schemes of combined pharmacotherapy including antiviral, anti-inflammatory drugs, glucocorticosteroids, genetically engineered biological drugs and "targeted" basic anti-inflammatory drugs were analyzed. The theoretical prerequisites for "repositioning" (drug repurposing) for the treatment of COVID-19 and ego complications are indicated. New directions of anti-inflammatory pharmacotherapy of COVID-19 Janus kinase with a range of anti-inflammatory and antiviral effects were noted. Emphasis was placed on the importance of informing health care professionals about forensic pharmaceutical risks in pharmacotherapy and vaccination practices. The relevance of legal support for medical activity in the conditions of a pandemic was noted. Further research is ongoing.
An interdisciplinary pharmacoeconomic study of pharmacotherapy for the relief of alcoholic dependence on the basis of experimental clinical and pharmacological, organizational, legal and marketing studies. The scheme of basic pharmacotherapy of relief of drunken forms of alcohol dependence developed by the authors for the interdisciplinary study was used. Thirteen international nonproprietary names of drugs from Ukrainian (92.3%) and foreign (7.7%) manufacturers were selected. It was established that for pharmacotherapy of support of relief of drunken forms of alcohol dependence tablets occupy 23,1% of appointments of doctors, solutions – 76,9%. The scheme of pharmacotherapy in the relief of intoxicated forms of alcohol dependence includes 38.5% of international nonproprietary names of drugs with ATC code "A" - drugs that affect the digestive system and metabolism; 30.7% with ATC code "B" - drugs that affect the blood system and hematopoiesis; 15.4% with ATC codes of classification "C" – drugs that affect the cardiovascular system and "N" – drugs that affect the nervous system. Nomenclature and legal analysis showed that 92.3% of the studied drugs belong to prescription nomenclature and legal group; the share of OTC drugs is 7.69% (international nonproprietary name Antral).
The article presents the results of the search for innovative technologies in a multidisciplinary study of the availability of COVID-19 vaccines of any type in the world. In the context of the coronavirus pandemic, multidisciplinary health research brings together the interdisciplinary links of scientists from around the world in medicine, pharmacy, law, economics on good medical practice, pharmaceutical provision and vaccination availability for all contingent of patients and postcovid health disorders. The aim of the research was to search for innovative technologies for the study of medically approved vaccines against COVID-19 in countries around the world using a multidisciplinary and integrated approach in the application of traditional and new methods of analysis. Content analysis was performed according to the range of licenses, permits for medical use and manufacturers by grouping them using the Sturgess formula, followed by construction of a discrete series of variations and distribution polygon. The results show satisfactory availability of vaccines against COVID-19 of any type. Doctors have a choice of appropriate vaccines and the manufacturer that corresponds to the social personalized vaccination taking into account the individual characteristics of patients.
An integrated ABC/VEN analysis of drug prescriptions in pharmacotherapeutic schemes for the relief of alcoholic dependence was performed. A retrospective analysis of seventy-five anonymized case histories of patients who sought medical help with drunken forms of alcoholic dependence was processed. The scheme of basic pharmacotherapy of relief of drunken forms of alcoholic dependence, developed by associate professor Yurii Chuiev for carrying out interdisciplinary study was used. Substantiated that the introduction of the developed innovative treatment algorithm, with the use of laser therapy, infusion therapy, anticonvulsants and hepatoprotectors allowed to create an effective treatment complex to alleviate this drug pathology. Pharmacoeconomic research was based on organizational and legal, clinical and pharmacological standards. Dosage forms of drugs according to medicinal purposes have been established in pharmacotherapeutic regimens for the relief of drunken forms of alcoholic dependence (tablets occupy 23.1% of appointments, solutions – 76.9%). The results of ABC analysis were given. Category A included seven INNs of drugs, the share of which was 81.13% of the total cost of pharmacotherapy of alcoholic dependence. Category B included four INNs of drugs with a cost share of 15.07%. In the category of C – two INNs of drugs with a share of costs of 4.80% for pharmacotherapy of relief of drunken states of alcoholic dependence. Overall, 85% of the studied drugs were included in pharmacotherapy as Vital, 15% as Essential. The results of the study can be used in conducting of budget tenders for the purchase of drugs, the rational use of drugs, the inclusion of drugs in regional and local forms for pharmacotherapy for the relief of drunken forms of drugs in healthcare facilities.
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