Today approximately 70% of patients with Hodgkin lymphoma can be cured with the combined-modality therapy. Tumor burden, the importance of which was demonstrated 15 years ago for the first time, is a powerful prognostic factor. Data of literature of representations on predictive value of Hodgkin's lymphoma tumor burden are shown in the article. The difficult immunological relations between tumor cells and reactive ones lead to development of the main symptoms. Nevertheless, the collective sign of tumor burden shows the greatest influence on survival and on probability of resistance, which relative risk can be predicted on this variable and treatment program. Patients with bulky disease need escalated therapy with high-dose chemotherapy. Integration into predictive models of the variable will change an expected contribution of clinical and laboratory parameters in the regression analyses constructed on patients with Hodgkin's lymphoma. Today the role of diagnostic functional methods, in particular a positron emission tomography, for metabolic active measurement is conducted which allows excluding a reactive component.
Учебное пособие используется для аудиторных занятий и самостоятельной работы студентов при изучении профилактики и лечения венозных тромбоэмболических осложнений у пациентов со злокачественными новообразованиями. Содержание освещает основные вопросы определения риска венозных тромбоэмболических осложнений и методы их профилактики и лечения у больных с местно-распространенными и метастатическими злокачественными новообразованиями. Учебное пособие предназначено для обучающихся в системе высшего образования (аспиранты, ординаторы, интерны, студенты) и дополнительного профессионального образования (слушатели циклов повышения квалификации). Учебное пособие утверждено в качестве учебно-методического пособия Ученым советом ФГБУ «НМИЦ онкологии им. Н. Н. Петрова» МЗ РФ (протокол № 10 от 27.09.2016).
The textbook is used for classroom studies and independent work of students in the study of prevention and treatment of venous thromboembolic complications in patients with malignant tumors. The content covers the main issues of determining the risk of venous thromboembolic complications and methods of their prevention and treatment in patients with locally advanced and metastatic malignant tumors. The textbook is intended for students in higher education (graduate students, residents, interns, students) and in additional professional education (students of advanced training cycles). The textbook was approved as educating manual by the Scientifi c Council of NMRC of Oncology n. a. N. N. Petrov HM of RF (protocol № 10 from 09.27.2016).
ОПУХОЛИ ЖЕНСКОЙ РЕПРОДУКТИВНОЙ СИСТЕМЫ TUMORS OF FEMALE REPRODUCTIVE SYSTEM Г и н е к о л о г и я / G y n e c o l o g y Г и н е к о л о г и я / G y n e c o l o g y Оригинальные статьи. Клинико-экономический анализ
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