Ceftaroline fosamil demonstrated high clinical cure and microbiological response rates in hospitalized patients with CAP of PORT risk class III or IV. Ceftaroline fosamil was well tolerated, with a safety profile similar to that of ceftriaxone and consistent with the cephalosporin class. In this study, ceftaroline fosamil was an effective and well-tolerated treatment option for CAP.

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BackgroundDelirium, a common problem among hospitalized elderly patients, is not usually diagnosed by doctors for various reasons. The primary aim of this study was to evaluate the effect of a short training course on the identification of delirium and the diagnostic rate of delirium among hospitalized patients aged ≥65 years. The secondary aim was to identify the risk factors for delirium.MethodsA prospective study was conducted in an acute-care hospital in Moscow, Russia. Six doctors underwent a short training course on delirium. Data collected included assessment by the confusion assessment method for the intensive care units, sociodemographic data, functional state before hospitalization, comorbidity, and hospitalization indices (indication for hospitalization, stay in intensive care unit, results of laboratory tests, length of hospitalization, and in-hospital mortality).ResultsDelirium was diagnosed in 13 of 181 patients (7.2%) who underwent assessment. Cognitive impairment was diagnosed more among patients with delirium (30.0% vs 6.1%, P=0.029); Charlson comorbidity index was higher (3.6±2.4 vs 2.3±1.8, P=0.013); and Barthel index was lower (43.5±34.5 vs 94.1±17.0, P=0.000). The length of hospitalization was longer for patients with delirium at 13.9±7.3 vs 8.8±4.6 days (P=0.0001), and two of the 13 patients with delirium died during hospitalization compared with none of the 168 patients without delirium (P=0.0001).ConclusionAlthough the rate of delirium was relatively low compared with studies from the West, this study proves that an educational intervention among doctors can bring about a significant change in the diagnosis of the condition.

Objective: To investigate whether better sexual health is associated with improvements in overall health and wellness, a more loving and intimate relationship, and a more positive outlook on life. Methods: The Sexual Health and Overall Wellness survey used self-administered questionnaires to collect data from men and women aged 25-74 years who had had sexual intercourse at least once within the previous 12 months. Results: Across nine countries, 3780 self-administered questionnaires were completed: 1893 from men (mean age, 44.6 years); 1887 from women (mean age, 44.2 years). The majority of men and women were satisfied with the frequency of sexual intercourse over the previous 4 weeks (59% and 66%, respectively); the majority (67% and 55%, respectively) reported that having sex was 'very important' or 'absolutely essential'. For men and women, there was a strong association between satisfaction with sex and overall health, and between satisfaction with sex and an overall positive outlook on life. Conclusion: For men and women, satisfaction with different aspects of sex was important, and was strongly associated with satisfaction with general health, relationships and other aspects of wellbeing.

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Within the framework of the Federal Project ‘Creation of a unified digital contour in health care based on the unified state information system of health care’ of the National Project ‘Healthcare’, employees of the Moscow State Medical and Dental University n.a. A. I. Evdokimov (Department of Therapy, Clinical Pharmacology and Emergency Medicine) with the assistance of RPO ‘Outpatient Doctor’ in 2020, a system for supporting medical decisions was created. The program ‘Hippocrates’ works in the testing mode, but now it is fulfilling the tasks assigned to it to increase the early detection of chronic diseases, and it also plays an important role in teaching doctors to take action based on clinical guidelines.

The effects of parenteral enaprilat were evaluated in hypertensive crisis (HC) with cerebral (hypertensive encephalopathy, stroke, transient ischemic attack) or cardiac (acute left ventricular failure, unstable angina) complications. The study covered 190 patients whose mean age was 64.8 years; there were 46 males and 144 females. Cerebral complications due to HC were observed in 119 patients; its cardiac complications were in 71. The decrease in blood pressure (BP) by 15-30 % of the baseline values with achieved diastolic BP less than 110 mm Hg was a criterion for the efficiency of therapy. Changes in clinical symptoms and outcomes were also taken into account. The treatment caused a significant decrease In BP and effective in 64, 80, 74, 72, and 82 % of the patients, respectively. Thus, the study demonstrated that intravenous enaprilat was highly effective in complicated arterial hypertension.