This review discusses current data on CNS lesions in infections with the new coronavirus that causes COVID-19. The pathogenetic mechanisms leading to infection of the brain and spinal cord are presented. Published studies and meta-analyses published by autumn 2020 are assessed. The authors present results from their own clinical observations of various types of CNS infection in COVID-19 virus disease. Particular attention is paid to certain common forms of CNS lesion such as encephalitis, cerebrovascular pathology, and headache. A form of acute hemorrhagic necrotic encephalopathy is identified, which is a quite rare but fatal pathology comorbid with COVID-19. A description of our own clinical observation of acute necrotic encephalopathy is presented. The importance of further studies of the effects of the coronavirus on the CNS and possible approaches to treatment and rehabilitation of this category of patients is emphasized.
Работа посвящена диабетической полинейропат ии-распространенности, возможностям диагностики, в том числе с применением инструментальных методов. Приведены собственные данные о возможностях выявления бессимтомных поражений периферической нервной системы у пациентов с сахарным диабетом. Показана эффективность терапии данного состояния с помощью одного из препаратов тиоктовой кислоты (Берлитион®).
ResultsOverall, 136 patients reverted from CM at baseline to EM during the DBP; 206 patients reverted during the OLE. Reductions from baseline in monthly migraine days, monthly headache days, and disability scores (6-item Headache Impact Test and Migraine Disability Assessment) achieved during the DBP were generally maintained or increased during the OLE, as were improvements in HRQoL, based on Migraine-specific Quality of Life domain scores (Table ).
ConclusionsMigraine patients with inadequate response by multiple prior migraine preventive medication classes who reverted from CM to EM achieved sustained, clinically meaningful reductions in migraine and headache days and improvements in disability and HRQoL over 6 months. .
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