The primary chemical mechanism of the beneficial medical/biological action of negative air ions necessary for life was studied. Air ion deficiency is the cause of many illnesses and treatment with air ion inhalation is effective in many cases. However, its application is limited by the absence of knowledge of the primary mechanism of its action. The superoxide anion O 2 was detected in the flow of negative air ions generated by an electroeffluvial air ionizer. Earlier, the appearance of hydrogen peroxide in solutions treated with air ions was shown. The presence of these reactive oxygen species in ultralow and low concentrations (10 12-10 6 M) suggested that the primary mechanism for the beneficial medical/biological action of negative air ions is moderate activation of free radical peroxidative oxidation within a physiological range that is lower than in tissues under pathology. It was shown in patients that treatment with inhalation of negative air ions did not induce pathological changes in superoxide dismutase activity and, under simultaneous administration of a food antioxidant, led to its mild increase. The latter, along with some previous results, supports the proposed mechanism. In addition, taking the proposed mechanism into consideration, air ion doses for treatment can be selected on an individual basis and should depend on the redox state of the patient. This should achieve better results for medical treatment with ionized air.
Abstract. Microwave plasma torches proposed in the world market are built according to a scheme that can be called classical: power supply -magnetron head -microwave isolator with water load -reflected power meter -matching device -actual plasma torch -sliding short circuit. The total cost of devices from this list with a microwave generator of 3 kW in the performance, for example, of SAIREM (France), is about 17,000 €. We have changed the classical scheme of the microwave plasmathrone and optimised design of the waveguide channel. As a result, we can supply simple and reliable sources of microwave plasma (complete with our low-budget microwave generator up to 3 kW and a simple plasmathrone of atmospheric pressure) at a price from 3,000 €.
SHORT COMMUNICATIONSWe recently developed a highly effective one-step procedure for solid-phase synthesis of heteroelementcontaining 1,3-azaenynes from acetylenic alcohols and primary amines by the action of MnO 2 -SiO 2 under microwave irradiation [1]. Surprisingly, in the reactions of 3-trimethylsilyl-and 3-triethygermyl-2-propynols I and II with 2-aminopyridine (III), which were performed under analogous conditions, we isolated 30% of imidazo[1,2-a]pyridine-3-carbaldehyde (VI) together with the expected Schiff bases R 3 MC≡C-CH=N-Py-2 (R 3 M = Me 3 Si, Et 3 Ge). Presumably, the formation of heterocyclic aldehyde VI is preceded by nucleophilic addition of 2-aminopyridine (III) at the triple bond of intermediate propynals IV and V. Next follows enamine-imine isomerization of β-aminoenal A into B and dehydrogenation according to path a in Scheme 1.Taking into account that 2-aminopyridines may be regarded as 1,3-difunctional nitrogen-centered nucleophiles [2], another reaction path is possible (path b in Scheme 1). This path implies reaction of propynals IV and V at the ring nitrogen atom of 2-aminopyridine (III) to produce zwitterionic intermediate C, which can be converted into imine D via intramolecular proton
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