An epoxy-containing copolymer was synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and allyl glycidyl ether. Further, the obtained copolymer was used to immobilize dopamine. It was found that immobilization of dopamine follows an equation of second general order and is accompanied by opening of the epoxy cycle. The synthesized dopamine-containing copolymer was used to produce hydrogels that are formed during the treatment thereof with solutions of iron(III) chloride and sodium periodate. The gel formed upon treatment with iron(III) chloride was found to be pH sensitive. It was shown that the hydrogel obtained through oxidation with sodium periodate is capable of complete slow degradation in a saline phosphate buffer at pH 7.5.
The kinetic curves for oxidation of dopamine hydrochloride in aqueous solution in the presence of ammonium peroxydisulfate were obtained by UV–vis spectroscopy and potentiometry. It was shown that the reaction follows the first‐order kinetic equation and proceeds at a low rate. The values for the activation energy and the preexponential factor were determined as 75 kJ × mol−1 and 4 × 108 s−1, respectively. The activation entropy was found having a negative value of −89 J × mol−1 × K−1. The first reaction order, the low preexponential factor and the negative activation entropy value for the reaction between the 2‐(3,4‐dihydroxyphenyl)ethanammonium cation and the peroxydisulfate anion were explained by the formation of ionic associates, which slowly enter into the internal redox reaction.
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