The study stresses the meaning of the physiological measures that are obtained with the functional diagnostics devices and how these values can be used in coaching sportsmen. Methods: Hemodynamic monitor was used for monitoring hemodynamics and heart function of athletes (n=305) with different fitness levels. Active orthoclinostatic tests and antiorthostatic tests with passive body position changing were carried out with hemodynamics measurements recorded. Results: The most informative indicators and indices of heart function for high performance sport and their values at rest were detected. Along with common hemodynamics indicators (HR, SV, CO, EDV, blood pressure, etc.) the possibility of using correlation rhythmogram in coaching was studied. The correlation rhythmogram "cloud" dependence on athletes' fitness level was revealed in transient during active orthoclinostatic test.
INTRODUCTION: To systematically review the literature for reported outcomes is studies on pregnant women with cardiac disease. METHODS: A search strategy was designed for Medline, Embase, Web of Science and Cochrane Central databases from 1980 to 2015 to identify all experimental and observational studies in pregnant women with cardiac disease. The search was limited to studies describing five patients or more, studies in the English language and excluded conference abstracts. As the intent was to describe reported outcomes, authors were not contacted for clarifications, the grey literature was not searched and no risk of bias assessment was performed. RESULTS: 3118 titles and abstracts were reviewed and 327 studies were included in this review, stratified under valvular heart disease (78), all cardiac disease (75), cardiomyopathies (68), complex congenital heart disease (49), cardiac interventions in pregnancy (35) and others including aortopathies and arrhythmias (22). There was large variation in the number and nature of reported outcomes. The most commonly reported maternal outcomes included: maternal mortality (n=169), thrombo-embolism (n=118), and mode of delivery (n=190). The most commonly reported fetal/neonatal outcomes included: preterm birth (n=143), miscarriage/abortion (n=119) and neonatal death (n=100). Proportions of studies that provided definitions for outcomes varied, and definitions were highly inconsistent between studies. CONCLUSION: Meta-analysis of studies involving pregnant women with cardiac disease requires consistency in the reporting and defining of outcomes for meaningful clinical conclusions to be drawn. To address this issue, a core outcome set, a standardized set of outcomes obtained through consensus between relevant stakeholders, is urgently required.
Background. Newborn infants who have undergone severe birth asphyxia have a high risk of neurological disorders and death. The most effective method for the treatment of hypoxic ischemic encephalopathy caused by intrapartum asphyxia is therapeutic hypothermia, or targeted temperature management. Currently, there are no large studies comparing its different methods, therefore the aim of our study was to compare the effectiveness of device-induced and uncontrolled therapeutic hypothermia in newborn infants who underwent intrapartum asphyxia.Materials and methods. Study design: we conducted a retrospective, longitudinal, cohort study in 39 newborn infants born in severe asphyxia and receiving uncontrolled therapeutic hypothermia (group 1), and in 48 newborn infants born in severe asphyxia and receiving device-induced therapeutic hypothermia (group 2). Statistical data processing was carried out using standard techniques.Results. The body temperature in newborn infants of both groups was reduced to 33.5 °C within the first hour, but when using uncontrolled therapeutic hypothermia, the body temperature fluctuated from 32 to 35 °C. Device-induced therapeutic hypothermia has a more effective neuroprotective effect as compared to uncontrolled hypothermia (p< 0.05) and more rapidly stabilizes metabolism in newborns due to a decrease in lactate levels (p < 0.05). In newborns device-induced therapeutic hypothermia stabilizes hemodynamics more quickly compared to uncontrolled therapeutic hypothermia (p < 0.05). Device-induced therapeutic hypothermia reduces the period of hospitalization in the neonatal intensive care unit (p < 0.05), the risk of cerebral edema (p < 0.05) and of the repeated episodes of seizures (p < 0.05). Conclusion. Using uncontrolled therapeutic hypothermia causes a high risk of unintentional fluctuations in rectal temperature towards both hypothermia and rewarming, which can aggravate the severe condition of newborn infants. Device-induced therapeutic hypothermia has a more effective neuroprotective effect.
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