The article contains Russian expert consensus statement on the diagnosis and treatment of fulminant myocarditis (FM), prepared by the National Society for the Study of Lipidology and Associated Metabolic Diseases, the Society of Internal, Sports and Preventive Medicine based on the clinical guidelines of the Russian Society of Cardiology, results of China Clinical Study (NCT03268642), Expert Guidelines of Russian Clinical and Research Center of Gerontology, Chinese Society of Geriatrics, Cardiology Branch of Beijing Medical Association. Pathogenesis, diagnosis and treatment of myocardial injury and FM in patients infected with SARS-CoV-2 in the context of the COVID-19 pandemic are discussed. Clinical features and diagnostic criteria of FM, as well as and comprehensive therapy for myocardial injury and FM are presented. The proposed protocol for the management of patients with myocardial injury in patients infected with SARS-CoV-2 was adapted with the clinical experience of Chinese experts. The protocol for anticoagulant and antiplatelet therapy was proposed by the Moscow State University Medical Center.
The creation of diagnostic tests to determine and monitor an athlete’s adaptation resources is a relevant task.Aim. To determine the levels of natural anti-glutamate receptor and anti-GABA antibodies in the dynamics of physical activity during training of football players. To establish the predictive role of these indicators in the objectification of adaptation.Material and methods. The experimental group involved 33 football players aged 18 to 24 years. The control group (n=33) consisted of volunteers of the same age engaged in fitness. Determination of immunological parameters was carried out by solid-phase ELISA.Results. It was found that each subject has an individual immunological profile, the parameters of which change depending on load received. The measured levels of anti-glutamate receptor and anti-GABA antibodies are consistent with the physical activity of a football player. According to the analysis results, the athletes were divided into three groups. The subjects of the first one had reliably high immunological indices and was at the peak of physical activity. Low values of the third group indicated a fatigue. The second group levels were within normal range and demonstrated resource capabilities for the load.Conclusion. The revealed immunological markers are suitable for the diagnostic and prognostic assessment of the athlete’s body functional state.
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