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a b s t r a c tDeveloped over the past three decades, the national innovation system concept (NIS) has been widely used by both scholars and policy makers to explain how interactions between a set of distinct, nationally bounded institutions supports and facilitates technological change and the emergence and diffusion of new innovations. This concept provides a framework by which developing countries can adopt for purposes of catching up. Initially conceived on structures and interactions identified in economically advanced countries, the application of the NIS concept to developing countries has been gradual and has coincided -in the NIS literature -with a move away from overly macro-interpretations to an emphasis on micro-level interactions and processes, with much of this work questioning the nation state as the most appropriate level of analysis, as well as the emergence of certain intermediary actors thought to facilitate knowledge exchange between actors and institutions. This paper reviews the NIS literature chronologically, showing how this shift in emphasis has diminished somewhat the importance of both institutions, particularly governments, and the political processes of institutional capacity building. In doing so, the paper suggests that more recent literature on intermediaries such as industry associations may offer valuable insights to how institutional capacity building occurs and how it might be directed, particularly in the context of developing countries where governance capacities are often lacking, contributing to less effective innovation systems, stagnant economies, and unequal development.

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As an EU policy agenda, the “knowledge-based bio-economy” (KBBE) emphasizes bio-technoscience as the means to reconcile environmental and economic sustainability. This frames the sustainability problem as an inefficiency to be overcome through a techno-knowledge fix. Here ecological sustainability means a benign eco-efficient productivity using resources which are renewable, reproducible and therefore sustainable. The KBBE narrative has been elaborated by European Technology Platforms in the agri-food-forestry-biofuels sectors, whose proposals shape research priorities. These inform policy agendas for the neoliberalization of both nature and knowledge, especially through intellectual property. In these ways, the KBBE can be understood as a new political-economic strategy for sustainable capital. This strategy invests great expectations for unlocking the productive potential of natural resources through a techno-knowledge fix. Although eco-efficiency is sometimes equated with biological productivity, commercial success will be dependent upon new combinations of “living” and “dead” labour

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The intraaortic balloon pump (IABP) is the single most effective and widely used device for temporary mechanical assistance of the failing heart. Although the principles underlying IABP function are simple, various biologic factors often determine its performance in a particularly complicated way. We briefly describe the basic disciplines of counterpulsation by IABP and the induced hemodynamic changes while clarifying the biologic mechanisms that play a crucial role in the modification of IABP acute hemodynamic performance.