Background: Generating ROS has become a novel anti-cancer approach. Results: NPP preferentially induces tumor cell apoptosis through P450-catalized ROS production. Conclusion: Cell susceptibility to ROS-induced death is influenced by cellular redox status, p53 mutation, STAT3 activation, and location of ROS production. Significance: Our study not only discovered a novel drug candidate but also shed new light on the understanding of ROS generation and function.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.