By comparing miRNA gene expression patterns in 3 types of CRS patients, we have been able to identify candidate miRNAs that might mediate the core pathogenesis of CRS through regulating dendritic cells. These miRNAs could serve as potential therapeutic targets for CRS.
Nasopharyngeal carcinoma (NPC) is a rare but highly invasive cancer that is prevalent among people of southern Chinese ancestry in southern China and Southeast Asia. Radiotherapy and cisplatin (CDDP)-based chemotherapy are the main treatment options. Unfortunately, disease response to concurrent chemoradiotherapy varies among patients with NPC, and many cases are resistant to CDDP and radiotherapy. NFBD1 functions in cell cycle checkpoint activation and DNA repair following DNA damage. In this study, we identified the NFBD1 as a tractable molecular target to chemosensitize NPC cells. NFBD1 expression in NPC CNE1 cell lines was depleted using lentivirus-mediated short hairpin RNA, and the elevated sensitivity of these NFBD1-inhibited NPC cells to therapeutic reagent CDDP and 5-fluorouracil (5-FU) was evaluated using MTS assays. Flow cytometry analysis also showed that NFBD1 knockdown led to an obvious induction of apoptosis in CDDP- or 5-FU-treated CNE1 cells. Furthermore, we implicated the involvement of NFBD1 in Rad51 and DNA-PKcs foci formation following CDDP or 5-FU chemotherapy. In conclusion, NFBD1 knockdown improves the chemosensitivity of NPC cells by inhibiting cell growth and promoting apoptosis through the impairment of DNA damage repair, suggesting NFBD1 as a novel therapeutic target for NPC.
ObjectivesThe aim of this study was to evaluate the impact of surgery and different
implant materials on subjective outcomes in patients with empty nose
syndrome (ENS).MethodsPostsurgical outcomes were assessed in a meta-analysis of patients with ENS
who underwent treatment with different implants.ResultsWe identified 122 relevant studies, and 6 were included in the meta-analysis
(4 prospective trials and 2 randomized controlled trials). A significant
difference was found between the preoperative and postoperative Sino-Nasal
Outcome Test (SNOT) scores for different implants. With respect to implant
materials, significant differences were observed between
autografts/allografts (AG) and foreign material grafts (FGs). A subgroup
analysis of different countries showed that more patients from China
underwent surgical implant therapy than patients from other countries.ConclusionsThis meta-analysis suggests that surgery can improve the symptoms and SNOT
scores of patients with ENS, AGs are more effective than FGs in patients
with ENS, and that more patients from China undergo surgical implant therapy
than patients from other countries.
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