Designing high-temperature polymers with excellent processability is a long-standing challenge because of the implacable contradiction between high thermal stability and low curing energy. Traditional designs based on scientific intuition and trial-and-error experiments have not been efficient strategies for the discovery of new heat-resistant resins. In this work, we developed a materials genome approach to facilitate the design of new heat-resistant resins with the desired properties. By defining the gene and extracting key features for properties, we proposed a two-step strategy to screen candidate resins obtained from combinations of genes. A new kind of heat-resistant resin was predicted by rapid screening and was further verified by theoretical simulations and experimental studies. The basic framework developed for the present materials genome approach can be generalized for the rapid design of other highperformance materials.
High-temperature phthalonitrile resins have a wide range of applications, and understanding their curing mechanism is of great importance for academic research and engineering applications. However, the actual curing mechanism is...
At the molecular level, intermolecular polymerization can compete with its intramolecular cyclization, which is known as a ring−chain competition reaction. However, this competitive phenomenon has rarely been observed in higherlevel systems. Herein, we report a supramolecular ring−chain competition reaction between the intermicellar polymerization and intramicellar cyclization of rodlike micelles assembled from rod− coil graft copolymers. Nanowires and toroidal micelles are the chain-like and ring-like products of the two supramolecular reactions, respectively. When the reaction conditions (solvent composition or temperature) are varied, the competition of the two supramolecular reactions is induced, and their dynamic competition relation and equilibrium constants can be regulated by the reaction conditions. The combination of experiments and theoretical simulations reveals that the interplay of the core/shell interfacial energy, the bending energy of rodlike micelles, and the end-capping energy determines such ring−chain competition. This study presents an advance in supramolecular self-assembly and provides a progressive way to construct complex hierarchical nanostructures.
Abstract. The aim of the present study was to compare the advantages and disadvantages of the combined application of recombinant human thyroid stimulating hormone (rhTSH) with thyroid hormone withdrawal (THW) and THW alone prior to 131 I therapy for the treatment of differentiated thyroid cancer. Four indicators were compared between the experimental group, who received a combined therapeutic method of rhTSH with THW, and the control group, who received THW therapy alone. With the exception of the elimination half-time of 131
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