Study HighlightsWHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Accurate prediction of tissue concentrations of a drug is important to understand its pharmacokinetic/pharmacodynamic (PK/PD) relationship. However, making such predictions is challenging, especially when the drug is a substrate of the tissue uptake and/or efflux transporters.
It is expected that utilization of in vitro data will further increase with the refinement of simulations. It is also anticipated that transporter humanized preclinical models have a significant impact and utility.
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