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in a karstified coastal system using density-dependent modelling and comparison with the sharp-interface approach. Hydrological Sciences Journal, 57 (5), 985-999.Abstract Saltwater intrusion is a naturally occurring phenomenon that is exacerbated significantly by excessive groundwater exploitation in coastal aquifers. In order to determine the extent of saltwater intrusion in a karstified coastal aquifer in Crete, Greece, a three-dimensional, density-dependent groundwater flow and transport model was developed and compared to the more traditional sharp-interface approach. The karstified medium was modelled using a combination of the equivalent porous medium approach (for lower-order fractures) and a discrete fracture approach (for the main fractures/faults). The model takes into consideration the geomorphologic characteristics of the karstic system, such as the depth and orientation of the fault network, and the diffusion phenomena associated with the variable densities of freshwater and saltwater-parameters that create a complex system, inducing uncertainty in the model. The model results showed that the orientation of the fractures, the pumping activity and the fluid density effects drive the seawater intrusion front asymmetrically inland.