Background: Today, nurses face with caring for Covid-19 patients, consider as a new occupational stressor in the nursing profession.Primary Study Objective: To investigate the effect of Benson's relaxation technique (BRT) on occupational stress of nurses exposed to Covid-19 patients.Methods/Design: The present study is a two-group clinical trial with parallel design.Setting: The samples were and randomly allocated into BRT and control groups based on the inclusion and exclusion criteria.Participants: 70 nurses working in the intensive care unit (ICU) in the Covid-19 treatment center in Sabzevar, IranIntervention: Intervention group were performed the BRT exercises twice a day for 1 month during 20 minutes each time. The data was collection through Osipow Occupational Stress Questionnaire. Primary Outcome Measures: Occupational stressResults: The mean occupational stress score in the BRT group immediately and after 1 week of intervention, was significantly lower than the control group (P = 0.001). The repeated measure analysis of variances test showed a significant difference in the mean occupational stress score in the 6 subscales after the intervention between the two groups (P < 0.05).Conclusion: This study showed BRT reduces occupational stress among nurses working in the ICU, caring for Covid-19 patients.Trial registration: IRCT, IRCT20131113015393N6. Registered 30 March 2020, https://en.irct.ir/trial/46609
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