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-The Rhodope Metamorphic Complex (RMC) is a high-grade crystalline massif located at the northern margin of the Aegean region. Numerous scenarios have been proposed for the evolution of the RMC during Alpine times. A debated issue is whether there has been a single protracted orogenic cycle since around the mid-Mesozoic or whether Alpine orogeny involved distinct episodes of subduction and crustal accretion. We describe a key outcrop located on the Nestos Shear Zone (NSZ), a major NNE-dipping top-to-SW shear zone characterized by an inverted metamorphic sequence. Structural and petrological data document the existence of two anatectic events. The first event, best preserved in decametric structural lenses, is pre-kinematic with respect to top-to-SW shearing and involved high-temperature "dry" melting. Zircon and monazite LA-ICPMS U-Th-Pb data indicate that this event occurred at ∼140 Ma. The second event is syn-kinematic with respect to top-to-SW shearing and involved lower-temperature water-assisted melting. Zircon and rutile LA-ICPMS U-Pb data indicate that this second event occurred at ∼40 Ma. During ongoing top-to-SW shearing and as late as ∼36 Ma, the rocks from the outcrop were at higher temperatures than the peak temperatures experienced by lower levels of the NSZ. This confirms the existence of the inverted metamorphic sequence and demonstrates that the NSZ was a major thrust at 36-40 Ma. The ∼100 Myr time laps between the two anatectic events encompasses the period from ∼115 to ∼70 Ma characterized by a gap in the geochronological record on the scale of the RMC (the Eastern Rhodope excluded). This ∼45 Myr gap likely reflects a period of tectonic quiescence between the mid-Mesozoic orogen and the Cenozoic one, attesting for polycyclic Alpine orogeny in the RMC. Unlike assumed in several geodynamic scenarios, the Alpine evolution of the RMC did not consist of a single orogenic cycle of Mesozoic age followed by Cenozoic crustal-scale extension triggered by mantle delamination. Polycyclic orogeny has resulted in a two-loop P-T-t path for the hangingwall unit of the NSZ. The Cenozoic P-T paths of this unit and the footwall unit merged while both units were being exhumed, a feature attributed to synthrusting extensional spreading of the main mass of the hangingwall unit above the NSZ.Keywords: Aegean / syn-deformation migmatization / U-Pb dating / LA-ICPMS / inverted metamorphism / synmetamorphic thrusting Résumé -Orogenèse alpine polycyclique dans le complexe métamorphique du Rhodope : enregistrement dans les migmatites de la zone de cisaillement du Nestos (Grèce). Le Rhodope est un complexe métamorphique de haut grade situé à la frange Nord de la région égéenne. De nombreux scénarios ont été proposés pour son évolution durant la période alpine. Une question débattue est de déterminer s'il n'y a eu qu'un seul cycle orogénique de longue durée depuis le milieu du Mésozoïque ou bien si l'orogenèse alpine a impliqué des épisodes distincts de subduction-accrétion crustale. Nous décrivons un affleurement-...

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