Acetylcholine, the first neurotransmitter identified more than a century ago, plays critical roles in human activities and health; however, its synaptic concentration dynamics have remained unknown. Here, we demonstrate the in situ simultaneous measurements of synaptic cholinergic transmitter concentration and release dynamics. We used nanoscale electroanalytical methods: nanoITIES electrode of 15 nm in radius and nanoresolved scanning electrochemical microscopy (SECM). Time-resolved in situ measurements unveiled information on synaptic acetylcholine concentration and release dynamics of living Aplysia neurons. The measuring technique enabled the quantitative sensing of acetylcholine with negligible interference of other ionic and redox-active species. We measured cholinergic transmitter concentrations very close to the synapse, with values as high as 2.4 mM. We observed diverse synaptic transmitter concentration dynamics consisting of singlet, doublet and multiplet events with a signal-to-noise ratio of 6 to 130. The unprecedented details about synaptic neurotransmission unveiled are instrumental for understanding brain communication and diseases in a way distinctive from extra-synaptic studies.
In the electrolysis of water process, hydrogen is produced and the anodic oxygen evolution reaction (OER) dominates the reaction rate of the entire process. Currently, OER catalysts mostly consist of noble metal (NM) catalysts, which cannot be applied in industries due to the high price. It is of great importance to developing low-cost catalysts materials as NM materials substitution. In this work, jarosite (AFe3(SO4)2(OH)6, A = K+, Na+, NH4+, H3O+) was synthesized by a one-step method, and its OER catalytic performance was studied using catalytic slurry (the weight ratios of jarosite and conductive carbon black are 2:1, 1:1 and 1:2). Microstructures and functional groups of synthesized material were analyzed using XRD, SEM, FI-IR, etc. The OER catalytic performance of (NH4)Fe3(SO4)2(OH)6/conductive carbon black were examined by LSV, Tafel, EIS, ECSA, etc. The study found that the OER has the best catalytic performance when the weight ratio of (NH4)Fe3(SO4)2(OH)6 to conductive carbon black is 2:1. It requires only 376 mV overpotential to generate current densities of 10 mA cm−2 with a small Tafel slope (82.42 mV dec−1) and large Cdl value (26.17 mF cm−2).
To mitigate the global greenhouse effect and the waste of carbon dioxide, a chemical raw material, high-purity γ-phase mesoporous alumina (MA) with excellent CO2 adsorption performance was synthesized by the direct aging method and ammonium salt substitution method. With this process, not only can energy consumption and time be shortened to a large extent but the final waste can also be recycled to the mother liquor by adding calcium hydroxide. Reaction conditions, i.e., pH value, aging time, calcination temperature, and desodium agent, were investigated in detail with the aid of X-ray fluorescence spectrum (XRF), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) and Barret-Joyner-Hallender (BJH) methods, nonlocal density functional theory (NLDFT), transmission electron microscopy (TEM), temperature-programmed desorption of CO2 (CO2-TPD), and presented CO2 adsorption measurement. The results of this study are summarized as follows: the impurity content of the MA synthesized under optimal conditions is less than 0.01%, and its total removal rate of impurities is 99.299%. It was found that the MA adsorbent has a large specific surface area of 377.8 m2/g, pore volume of 0.55 cm3/g, and its average pore diameter is 3.1 nm. Under the condition of a gas flow rate of 20 cm3/min, its CO2 adsorption capacity is 1.58 mmol/g, and after 8 times of cyclic adsorption, the amount of CO2 adsorption remained basically unchanged, both of which indicate that the material has excellent adsorption properties and can be widely used for the adsorption of carbon dioxide.
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