A carbon nanotube (CNT) supported single-site Fe-N-C
catalyst (CNTs/Fe-N-C)
exhibited attractive properties in peroxidase (POD)-like activity
and photothermal effect. Herein, we designed a therapeutic platform
by wrapping doxorubicin (DOX) in mesoporous CNTs/Fe-N-C with the cell
membrane (CM) of breast cancer. The ultimate nanoagent (CNTs/Fe-N-C/DOX/CM)
exhibited high antitumor activity on account of its efficient catalytic
ability, increased drug release rates, and significant photothermal
effect. Due to the POD-like activity, CNTs/Fe-N-C could effectively
catalyze hydrogen peroxide (H2O2) into cytotoxic
hydroxyl radicals (•OH) for chemodynamic therapy
(CDT) of the tumor. Besides, the released DOX not only merely induced
the diagnosis of the tumor cells for chemotherapy (CT) but also generated
H2O2 to promote CDT. Moreover, the photothermal
effect of the nanoagent could use for photothermal therapy (PTT).
The increasing temperature was conducive to the release of DOX from
micropore into the cell, which indirectly enhanced CT and CDT effects.
As an intelligent and multifunctional drug delivery platform, the
present CNTs/Fe-N-C/DOX/CM nanoagent could be engineered with synergistic
treatments and favorable biosafety, which provides a promising paradigm
in site-specific antitumor treatment and biomedicine.
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