No abstract

Abstract:Background: Adherence to oral bisphosphonates is often low, but even adherent patients may remain at elevated fracture risk. The goal of this study was to estimate the proportion of bisphosphonate-adherent women remaining at high risk of fracture.

No abstract

No abstract

The relationships between HIV infection, monocyte activation, and endothelial colony forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14+CD16+), and non-classical monocytes (CD14dimCD16++) levels in HIV-infected participants virologically-suppressed on antiretroviral therapy, HIV-infected treatment-naïve participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected, virologically-suppressed group compared to the uninfected controls. CD14+CD16+ percentages (but not CD14dimCD16++ cells) were significantly higher in both HIV-infected groups vs uninfected controls. In the HIV-infected groups, ECFCs and CD14+CD16+ intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV.