A new sesquiterpenoid, O-methyl nakafuran-8 lactone (1) has been isolated from a Hainan sponge Dysidea sp. and the structure of the new compound proposed by spectral data, was confirmed by X-ray diffraction analysis. The complete 1H- and 13C-NMR assignments were made on the basis of detailed 2D NMR spectral analysis. Compound 1 showed strong inhibitory bioactivity against PTP1B with IC50 value of 1.58 microM.
A new sulphonoglycolipid, crassicaulisine, has been isolated from the red alga Chondria crassicaulis Harv.. Four known compounds were also found from the title plant. The structure of the new compound was elucidated on the basis of chemical reactions and spectroscopic analysis.
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