Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier function, and dysregulated host responses to microbial stimulation. Strategies that target the microbiota have emerged as potential therapies and, of these, probiotics have gained the greatest attention. Herein, we isolated a strain of Lactobacillus paracasei R3 (L.p R3) with strong biofilm formation ability from infant feces. Interestingly, we also found L.p R3 strain can ameliorate the general symptoms of murine colitis, alleviate inflammatory cell infiltration and inhibit Th17 while promote Treg function in murine dextran sulfate sodium (DSS)-induced colitis. Overall, this study suggested that L.p R3 strain significantly improves the symptoms and the pathological damage of mice with colitis and influences the immune function by regulating Th17/Treg cell balance in DSS-induced colitis in mice.

The theory of Behavioral Immune System (BIS) posits that to cope with pandemic stress, human beings have evolved a series of behavioral responses, including vigilance to and disgust of disease cues, preference for healthy mate and collectivism, prejudice against out-groups and so on. For the first time, the existing studies were reviewed according to research level (individual vs. group). A large body of supportive evidence for BIS at both levels was identified, though many inconsistent and/or conflicting findings exist. Reasons leading to such inconsistencies include inadequacies of research methods, theory basis, and applicability in modern society. Future research should examine the boundary conditions of existing findings and theory; extend the scope of the current research; explore the underlying biological and physiological mechanism of BIS.

Purpose To clarify the implementation of the admission process under the public crisis of COVID-19 pandemic. Methods A real-world study was conducted to collect data on the normal and public crisis situations at a tertiary hospital in China and understand the views of 18 head nurses on the necessity of the admission process in public crisis situations. Independent t -test and chi-square test were used to analyze the work data in two situations; Spearman correlation analysis was performed to determine the correlation of work data with two situations of process implementation, and differences between the head nurses’ views of necessity of the admission process and actual implementation under public crisis situations were analyzed. Results Significant differences were observed in the working data between the normal and public crisis situations ( P < 0.05), and the implementation of the admission process was not in place. The number of nurses on duty was positively correlated with each item of admission process ( P < 0.05), the rest of work data were negatively correlated with each item in the admission process ( P < 0.05), and there was a significant difference between the necessity of each item in the admission process and the actual implementation results ( P < 0.05). Conclusion Public crisis leads to the lack of implementation of admission process, and the original admission process and quality control standards are not applicable during the public crisis situation.

Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier function, and dysregulated host responses to microbial stimulation. Strategies that target the microbiota have emerged as potential therapies and, of these, probiotics have gained the greatest attention. Herein, we isolated a strain of Lactobacillus paracasei R3 (L.p R3) with strong biofilm formation ability from infant feces. Interestingly, we also found L.p R3 strain can ameliorate the general symptoms of murine colitis, alleviate inflammatory cell infiltration and inhibit Th17 while promote Treg function in murine DSS-induced colitis. Overall, this study suggested that L.p R3 strain significantly improves the symptoms and the pathological damage of mice with colitis and influences the immune function by regulating Th17/Treg cell balance in DSS-induced colitis in mice.