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In transdermal drug delivery systems, the physicochemical properties of the drug affect its percutaneous permeability. However, whether the physicochemical properties of drugs change their transdermal permeability in the presence of pores in the presence of solid microneedles (MNs) has been less studied in this area. In this project, cinnamaldehyde, curcumin, ferulic acid and geniposide were selected as model drugs for the study of their transdermal permeability under the action of MNs, and a combination of classical experiments and visualization means such as scanning electron microscopy and laser confocal was used to investigate the permeation-promoting mechanism of MNs. The results showed that the MNs had significant permeation-promoting effects on different properties of drugs, with the permeation-promoting effects on cinnamaldehyde, curcumin, ferulic acid and geniposide being 6.36, 17.43, 29.54 and 8.91 times, respectively, and the permeation-promoting effects were more pronounced for lipid-soluble and amphiphilic drugs. Using scanning electron microscopy, transmission electron microscopy and other means to confirm that MNs can promote the penetration by acting on the skin to produce pores, and their effect on skin structure is greater than that of drugs. In addition, the existence of pores increases the amount of drug transdermal, which may enhance the diffusion of drug on the skin, and has no effect on lipid exchange and transdermal route. Through the research, it has been found that MNs is equivalent to direct peeling of the stratum corneum (SC), but it is simpler and safer for the patient.

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This essay studies the knowledge investment coordinating mechanism of the core enterprise, which plays both the role of the platform innovation ecosystem manager and the role of knowledge investment in the cooperative product development in the platform innovation ecosystem. The study shows that the profit distributed to the core enterprise and the agent enterprises of the platform innovation ecosystem is positively correlated with the impact weight of their knowledge investment on the knowledge production value, i.e. the higher the impact weight is, the more profit they may gain, that the larger the number of the agent enterprises in the platform innovation ecosystem is, the higher level of knowledge investment effort the core enterprise will make, the larger the core enterprise's total gain will be, and that the higher the higher the knowledge coordination degree between the core enterprise and the agent enterprises is, the larger the core enterprise's total gain will be.

By considering the symbiosis between rest behavior with charging behavior during intercity traveling, the inconvenience of battery electric vehicles (BEVs) confined by the battery capacity can be relieved. This paper proposed a quantitative analysis method for revealing this phenomenon from an accessibility perspective. This proposed method involved a calculation model of intercity travel time for electric vehicle by considering the current configuration of electric vehicle charging facilities and energy consumption with travel speed. Based on the highway network and charging pile network in Beijing-Tianjin-Hebei region, a case study has been analyzed to verify the feasibility of the model. The results show that the accessibility performance of BEVs and fuel vehicles is close in Beijing Tianjin Hebei region, which has relatively perfect charging facilities. And by joint the charging behavior and rest behavior, there is almost no difference between BEV models with a large range and advanced charging technology and fuel vehicles in intercity travel. In addition, the charging facilities along the expressway in the region can basically satisfy the experience of intercity travel for BEVs, and further increasing the number of charging stations cannot significantly improve the accessibility of electric vehicles.

Abstract. This paper analyzes the human resource management thought of Mr. SunYat-sen from the aspects of selection, education, employment and encouragement. In the selection, Sun Yat-sen advocates using examination and election methods to select talent, adhering to taking both ability and political integrity as talent selection criteria. In education, Sun Yat-sen advocates focusing on improving the quality of people, implementing the education for all and compulsory education, using multi-channel to train people. In the employment aspect, he advocates "make the best use of people and talent", adheres to "use the sagacious person", advocates abolition of life-long system and oppose "reward contribution with official post"; in encouraging people, he advocates giving create inventors high rewards, stimulating talents with fat salary, strengthening supervision and inspiring people with cause. In practice, he set an example, inspired the world.