Herein, we report a significant improvement in solar-pumped laser collection efficiency based on end-side pumping a 6-mm-diameter 95-mm-length Ce:Nd:YAG/YAG grooved bonded crystal rod. A Fresnel lens, quartz cooling-water tube, and gold-plated conical cavity constituted the solar-energy collection and concentration system, which was designed to maximum pump light absorption and minimize thermal effects in the Ce:Nd:YAG laser medium. To the best of our knowledge, this is the first time that a Ce:Nd:YAG crystal has been pumped by a Fresnel-lens solar-energy collection and concentration system. The 0.69-m2 effective solar-collection area produced 26.93 W of continuous-wave laser power, corresponding to 6.33% slope efficiency. The collection efficiency (38.8 W/m2) was 1.21 times higher than the highest previously reported value for Fresnel-lens solar collection, and is a record for single-beam solar-pumped lasers.

To evaluate the association between severe pulmonary embolism events and bevacizumab, we conducted the first meta-analysis evaluating the incidence and risk of pulmonary embolism associated with bevacizumab-based therapy. We searched PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov up to September 2016 for randomized controlled trials comparing bevacizumab with no bevacizumab on cancer patients. Incidence rates, relative risks, and 95% confidence intervals were calculated using fixed- or random-effects models. The primary end point was the association of bevacizumab with pulmonary embolism. Subgroup analyses were performed according to tumor type, dose, and publication status. In total, 23 randomized controlled trials were included. For patients receiving bevacizumab, the overall incidence of severe pulmonary embolism events was 1.76% (95% confidence interval = 1.25%-2.27%). Cancer patients treated with bevacizumab did not increase the risk of pulmonary embolism events (relative risk = 1.00, 95% confidence interval = 0.80-1.25). No significant differences in pulmonary embolism incidence or risk among subgroup analyses were observed. No evidence of publication bias was observed. This study suggested that bevacizumab may not increase the risk of pulmonary embolism in cancer patients.

Realizing a high solar light conversion magnitude in Cr,Nd: YAG transparent ceramic is crucial to its applications in solar pumped solid state lasers. In this study, high quality Cr,Nd:YAG transparent laser ceramics with homogeneous microstructure and theoretical transmittance were fabricated, and an efficient laser oscillation of watt-level was realized by pumping ceramic at 808 nm. There were no any characteristic absorptions corresponding to Cr2+ or Cr4+ ions detected, even when the Cr3+ ion doping concentration reached 0.6 at.%. Increasing Cr3+ and Nd3+ doping concentrations significantly enhanced the emission intensity of ceramics at 1.06 µm, and energy transfer efficiency of the 0.3 at.% Cr,Nd: YAG ceramics was increased from 14.9% to 36.9% when increasing Nd3+ ion concentration from 0.3 at.% to 1.0 at.%, with an increasing magnitude of 247.6%. The results indicated that Cr,Nd: YAG transparent ceramic is a promising gain medium for solar pumped solid state lasers.

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Solar-pumped lasers (SPLs) allow direct solar-to-laser power conversion, and hence, provide an opportunity to harness a renewable energy source. Herein, we report significant improvements in end-side-pumped solar laser collection efficiency and beam brightness using a novel 1.5-m-diameter compound solar concentrator combining a Fresnel lens and modified parabolic mirror. A key component of this scheme is the off-axis-focused parabolic mirror. An original dual-parabolic pump cavity is another feature. To determine the dependence of the SPL performance on the distance between the focus and central axis of the modified parabolic mirror, several systems with different distances were optimized using TracePro and ASLD software. It was numerically calculated that end-side pumping a 5-mm-diameter, 22-mm-long Nd:YAG crystal rod would generate 74.6 W of continuous-wave solar laser power at a collection efficiency of 42.2 W/m2, i.e., 1.1 times greater than the previous record value. Considering the laser beam quality, a brightness figure of 0.063 W was obtained, which is higher than that of other multimode SPL designs with end-side pumping. Thus, our SPL concentrator offers the possibility of achieving a beam quality as high as that obtainable via side pumping, alongside highly efficient energy conversion, which is characteristic to end-side pumping.

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