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The Massachusetts Eye and Ear Infirmary (MEEI) database is an international-standard training database for voice pathology detection (VPD) systems. However, there is a class-imbalanced distribution in normal and pathological voice samples and different types of pathological voice samples in the MEEI database. This study aimed to develop a VPD system that uses the fuzzy clustering synthetic minority oversampling technique algorithm (FC-SMOTE) to automatically detect and classify four types of pathological voices in a multi-class imbalanced database. The proposed FC-SMOTE algorithm processes the initial class-imbalanced dataset. A set of machine learning models was evaluated and validated using the resulting class-balanced dataset as an input. The effectiveness of the VPD system with FC-SMOTE was further verified by an external validation set and another pathological voice database (Saarbruecken Voice Database (SVD)). The experimental results show that, in the multi-classification of pathological voice for the class-imbalanced dataset, the method we propose can significantly improve the diagnostic accuracy. Meanwhile, FC-SMOTE outperforms the traditional imbalanced data oversampling algorithms, and it is preferred for imbalanced voice diagnosis in practical applications.

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