α-Aminophosphonates play an important role across several fields, including organic synthesis and various potential applications. This review paper surveys recent achievements in the synthesis of α-Aminophosphonates, it summarizes the main synthetic routes towards α-Aminophosphonates that are known and it describes their biological proprieties from January2010 till December 2020: Special attention is devoted to green chemical approaches including catalysts, ultrasonic and microwave irradiations. We hope this paper will be a useful resource for researchers and that it will help them to work in this emerging research area.
An efficient access to a novel series of organophosphorus compounds with a cyclosulfamide moiety is described. Starting from α-hydroxyphosphonates, the 2-chloroethyl-(1, 2, 5-thiadiazoline-2-carbonyloxy-1-dioxide) phosphonates compounds were prepared in three steps including an Abramov reaction, carbamoylation-sulfamoylation with chlorosulfonyl isocyanate and an intramolecular cyclisation. The spectroscopic methods( 1 H NMR, 13 C NMR, 31 P NMR, MS and IR) were used to determine the structural characteristics of the synthesized compounds and X-ray crystallographic data were provided for compound 3c. Some selected compounds were screened in vitro for their antimicrobial activity against a panel of microorganisms, resulting in a good antibacterial activity compared to standard drugs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.