The most commonly prescribed medication for autoimmune disorders is Azathioprine (AZA), which negatively affects renal function and tissue structure. The aim of this work was to measure the therapeutic impact of Zingiber officinale L. extract (ZOE) on improving the function and structure of AZA-induced renal damaged tissue. Methods: 70 rats with a weight range of 200±10 g and an age of 95±5 days were chosen for this experimental study. The animals were grouped into seven groups of ten, with two groups receiving no treatment (control groups) and five groups receiving ZOE, AZA, “AZA + ZOE”, and normal saline. AZA was given intraperitoneally, and ZOE was given by gavage (i.e., nasogastric tube) for 21 days. Finally, urea, uric acid, creatinine parameters, and the diameter of some key or important parts of the kidney were measured in different animal groups. Results: it was found that the use of AZA (50 mg/kg) increased serum urea and creatinine concentrations, blood uric acid in comparison to the group of control (P<0.05). Whereas injecting ZOE (200 mg/kg) induces a considerable decrease in the concentration of the compounds mentioned above as compared to control animals and animals given AZA (P<0.05). Furthermore, the findings revealed that AZA caused inflammation and kidney tissue destruction, while ZOE improved, restored, and recovered the affected kidney tissue. Conclusion: according to the research findings, it can be decided that ZOE has a protective and therapeutic impact on kidney tissue owing to its strong antioxidant attributes and its ability to inhibit free radicals produced by azathioprine
Depression is one of the most common mental disorders and numerous medications are used to reduce the psychotic symptoms. The aim of this study was to evaluate the therapeutic effects of two commonly used antidepressant drugs, including Fluoxetine (Flx) and Imipramine (IMP) to improve depressive-like behaviors as well as the activity of hypothalamic pituitary-adrenal cortex (HPA). Methods: Initially, 40 adult male albino rats weighing 25±5g were selected for this experimental study. The animals were kept or housed in separate cages under standard temperature (25±1°C) and light-dark conditions (12 hours light/dark cycle). Rats were divided into four groups: each group containing 10 rats, control, immobility stress, Flx receiver, and IMP receiver. Polyethylene restrainer was used to induce immobility stress for 14 days. Finally, the parameters of IMT, ST, serum levels of corticosterone and glucose were evaluated in all four mentioned groups. Results: The results showed that the patient group's immobility time (IMT) increased compared to the control group, but the patient group's swimming time (ST) decreased compared to the control group. The effect of immobility stress on IMT, ST, corticosterone, and glucose factors in the patient group was increasing and decreasing, respectively, whereas the effect of Flx drug on these mentioned factors was decreasing, increasing and respectively, while the effect of IMP on all mentioned factors was decreasing and increasing, respectively. Conclusion: Based on the results, it can be concluded that the antidepressant Flx and IMP drugs have various effects on the HPA activity, and the application of immobility stress causes depressive-behavior. Moreover, Flx is more effective than IMP in the treatment of depressive behaviors
Background: One of the most common gastrointestinal diseases is gastric ulcer (GU). The ethanolic extract from the aerial part of Zinnia elegans was created to test its ability to protect the gastric mucosa from damage caused by ethanol in mice. Method: Zinnia elegans ethanolic extract was administrated intragastrically once daily for three days. After the final intragastric dose, gastric ulcer in mice was created on the third day using 70% ethanol. The stomach tissues were extracted to assess the severity of the gastric mucosal changes. Results: Orally administered Zinnia elegans ethanolic extract reduced the severity of stomach mucosal changes. In addition, the levels of tumor necrosis factor‐α (TNF‐α), interleukin-1B (IL‐1β), and tool-like receptor (TLR4) activity in stomach tissues were all dramatically reduced after oral administration of the extract. These findings demonstrate that the anti-inflammatory properties of Zinnia elegans ethanolic extract protect against ethanol-induced stomach mucosal damage in mice. Conclusions: The results of this investigation offer some support for the creation of new treatments for stomach ulcers as an alternative to treating gastric damage brought on by alcohol consumption.
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