The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cellsurface receptor for members of the epidermal growth factor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelian tumors of the neck and head, leading to the development of anticancer therapeutics targeting EGFR. The EGFR Kinase Assay Kit is designed to measure EGFR Kinase activity for screening and profiling applications using Kinase-Glo ® MAX as a detection reagent. The EGFR Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant EGFR enzyme, EGFR substrate, ATP and Kinase Buffer 1 for 100 enzyme reactions.
New 3-(3,4-dimethoxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one has been designed as a starting compound to synthesis a novel series of substituted pyrido [2,3-d]pyrimidine system incorporated to different Schiff's bases and enamine derivatives as potent antimicrobial compounds. Novel synthesized compounds were evaluated for their in-vitro antimicrobial potency against different Gram positive and Gram negative bacteria; namely Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella and Candida albicans strain; where they reveal high effectuality at low concentration compared to Trimethoprim. Docking studies declared that new pyrido [2,3-d] pyrimidines completely occupied active pocket of Biotin Carboxylase of both bacterial types and fungal strains acting as selective Fatty Acid Synthesase type II inhibitors. In addition, structure-activity relationship was discussed.
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