Lupin is a nonstarchy grain legume with high protein, dietary fibre and low fat contents. The industrial shift of lupin seed utilisation from feed to food has recently increased the scientific interest to explore its phytochemical composition and biological activities. Lupin seeds contain significant amounts of polyphenols, carotenoids, phytosterols, tocopherols, alkaloids and peptides with antioxidant, antimicrobial, anticarcinogenic and anti-inflammatory activities. Among polyphenols, genistein and their derivatives (isoflavones) are of great importance because of their phytoestrogenic potential. This comprehensive review will help out the readers in understanding the phytochemicals present in lupin and their benefits.

Background.The Thinking Healthy Programme (THP) is an evidence-based psychological intervention endorsed by the World Health Organization, tailored for non-specialist health workers in low- and middle-income countries. However, training and supervision of large numbers of health workers is a major challenge for the scale-up of THP. We developed a ‘Technology-Assisted Cascaded Training and Supervision system’ (TACTS) for THP consisting of a training application and cascaded supervision delivered from a distance.Methods.A single-blind, non-inferiority, randomized controlled trial was conducted in District Swat, a post-conflict area of North Pakistan. Eighty community health workers (called Lady Health Workers or LHWs) were randomly assigned to either TACTS or conventional face-to-face training and supervision by a specialist. Competence of LHWs in delivering THP post-training was assessed by independent observers rating a therapeutic session using a standardized measure, the ‘Enhancing Assessment of Common Therapeutic factors’ (ENACT), immediately post-training and after 3 months. ENACT uses a Likert scale to score an observed interaction on 18 dimensions, with a total score of 54, and a higher score indicating greater competence.Results.Results indicated no significant differences between health workers trained using TACTS and supervised from distancev.those trained and supervised by a specialist face-to-face (mean ENACT score M  =  24.97,s.d.  =  5.95v.M =  27.27,s.d.  =  5.60,p  =  0.079, 95% CI 4.87–0.27) and at 3 months follow-up assessment (M  =  44.48,s.d.  =  3.97v.M =  43.63,s.d.  =  6.34,p  =  0.53, CI −1.88 to 3.59).Conclusions.TACTS can provide a promising tool for training and supervision of front-line workers in areas where there is a shortage of specialist trainers and supervisors.

Purpose Cyberloafing is the personal use of internet while at work. The purpose of this paper is to identify the factors affecting cyberloafing between public and private sector organizations. Design/methodology/approach This study uses the multiple motivational factors with the help of a theoretical paradigm, renowned as theory of interpersonal behavior (TIB). Data were collected through questionnaire to investigate the different behavioral factors between the public and private sector organizations. PLS path modeling and PLS-MGA are used to access the results on SMARTPLS 2.0 software. Findings Results show that the three factors of habit, intention, and social influences taken from the TIB model are important and have a higher path coefficient in a public sector organization setting. The factors of affect, facilitating condition and perceived consequences from TIB are greater in a private sector organization and have a higher path coefficient. By contrast, in multiple group analysis, results show that some factors are more predictive of cyberloafing behavior in a public sector organization, whereas other factors are more predictive for a private sector organization. Practical implications The findings of the current research are beneficial for both organizations and contribute toward policy-making decisions. These results help the managers of public and private sector organizations to decide how to control cyberloafing behavior by focusing on the important factors that lead to it. Originality/value This study shows strong and significant differences between the two types of organizations in terms of path coefficient. This implies that cyberloafing factors have different impacts on different organizations. The study fills an important gap in comparing public and private sector organizations with respect to cyberloafing behavior and clarifying which factors are more effective in predicting cyberloafing behavior according to type of organization. The paper is of great value for both kinds of organizations that face cyberloafing behavior issues.

Background With the development of evidence-based interventions for treatment of priority mental health conditions in humanitarian settings, it is important to establish the cost-effectiveness of such interventions to enable their scale-up. Aims To evaluate the cost-effectiveness of the Problem Management Plus (PM+) intervention compared with enhanced usual care (EUC) for common mental disorders in primary healthcare in Peshawar, Pakistan. Trial registration ACTRN12614001235695 (anzctr.org.au). Method We randomly allocated 346 participants to either PM+ (n = 172) or EUC (n = 174). Effectiveness was measured using the Hospital Anxiety and Depression Scale (HADS) at 3 months post-intervention. Cost-effectiveness analysis was performed as incremental costs (measured in Pakistani rupees, PKR) per unit change in anxiety, depression and functioning scores. Results The total cost of delivering PM+ per participant was estimated at PKR 16 967 (US$163.14) using an international trainer and supervisor, and PKR 3645 (US$35.04) employing a local trainer. The mean cost per unit score improvement in anxiety and depression symptoms on the HADS was PKR 2957 (95% CI 2262–4029) (US$28) with an international trainer/supervisor and PKR 588 (95% CI 434–820) (US$6) with a local trainer/supervisor. The mean incremental cost-effectiveness ratio (ICER) to successfully treat a case of depression (PHQ-9 ≥ 10) using an international supervisor was PKR 53 770 (95% CI 39 394–77 399) (US$517), compared with PKR 10 705 (95% CI 7731–15 627) (US$102.93) using a local supervisor. Conclusions The PM+ intervention was more effective but also more costly than EUC in reducing symptoms of anxiety, depression and improving functioning in adults impaired by psychological distress in a post-conflict setting of Pakistan.

We report a simple and economical colorimetric bacterial sensing strategy with catalytic amplification using dopamine-capped iron oxide (Dop-Fe3O4) nanoparticles. These nanoparticles catalyse the oxidation of a chromogenic substrate in the presence of H2O2 into a green colored product. The catalytic activity of the nanoparticles is inhibited in the presence of bacteria, providing naked eye detection of bacteria at 104 cfu/mL and by spectrophotometric detection down to 102 cfu/mL.

Nano/microscale TiO 2 materials and their composites have reached the pinnacle of their photocatalytic performances to destroy persistent organic pollutants and waterborne microorganisms, but their practical applications are limited by the drawbacks associated with their stability, leaching, processing and separation. To overcome these shortcomings, we have prepared hierarchically porous nanostructured TiO 2 macrobeads via an exotemplating or nanocasting strategy by infiltrating the TiO 2 sol into the emulsion-templated porous polyacrylamide scaffold followed by its gelation, drying and calcination. The nanoscale TiO 2 building units tailor the shape of the porous polymeric network after calcination thereby retaining the macroscale morphology of polymer beads after template removal. A novel combination of the hierarchical macroporosity, orderly crystalline anatase nature, nanoscale feature and good surface area revealed by the relevant characterization tools makes these TiO 2 scaffolds particularly effective for superior degradation of methylene blue with the enhanced rate constant and efficient disinfection of E. coli and S. aureus under UV light. The macrosize and mechanical stability of these purely TiO 2 beaded architectures have several potential advantages over conventional TiO 2 nanocomposites and slurry systems to address the inherent bottlenecks of secondary contamination, difficult operation and energy-intensive post-recovery processes that are indeed deemed to be the barriers to develop practically useful water treatment technologies.

Microwave‐assisted extraction (MAE) method was investigated to recover phenolic compounds from carob kibbles and validated using response surface methodology. The study parameters were microwave power (170–900 W), ethanol concentration (30–90%), and solvent‐to‐sample ratio (10–30 mL/g) in terms of total phenolic content (TPC) and condensed tannins. Among optimized parameters (340 W, 45%, 30 mL/g), microwave power and ethanol concentration were found more influential parameters to get higher yields of TPC and condensed tannins. Moreover, the results of TPC (70.11 mg GAE g−1 DM), condensed tannins (4.11 mg CE g−1 DM), free radical scavenging activity (94.42%), ferric ion reducing potential (22.67 mg Fe+3 100 g−1 DM), and gallic acid (1.576 mg/g DM) obtained from optimal MAE conditions were found comparable to ultrasound‐assisted extraction method. The newly developed MAE method illustrates its potential to recover phenolic compounds from plant sources in a short duration. Practical applications Based on the results presented in this work, it is proposed that carob kibble could be considered as interesting raw material to get extracts rich in antioxidant properties. This extract could be used as an alternative to synthetic antioxidants in bio‐food products as natural preservative. Therefore, carob kibbles could be recommended for production of extracts rich in antioxidants, instead of being discarded from gum factory as by‐product. In addition, microwave‐assisted extraction method could be employed to increase time efficiency of the process.

BackgroundDepression is common among elderly in developed countries and it is more pronounced in institutional settings. In Pakistan there is a lack of empirical data on depression among this segment of the population particularly with reference to their living arrangements.The objectives of the present study are to report the magnitude of depression among elderly having two different residential arrangements and to examine the association of depression and its established demographic factors.FindingsData were collected from 141 respondents. 108 were community residents (m = 57 and f = 51) and 33 were living in the care homes (m = 29 and f = 4).Prevalence of depression as assessed by Geriatric Depression Scale (GDS) among community and Care Homes (CHs) participants was 31.5 percent and 60.6 percent, respectively.On Centre of Epidemiological Studies Depression Scale (CES-D), 42.6 percent of the community and 69.7 percent of the CH respondents were deemed depressed. Before adjusting for any other potential risk factors the odds of being depressed was significantly increased if the study participants were living in CH, relatively older, female, not currently married, had low educational level, had lower Mini Mental State Examination (MMSE) scores, and reported lower perceived emotional and practical support. In a partially adjusted logistic regression model an increased risk of depression was not confounded by any of the above mentioned risk factors.However, the risk associated was not significant when it was adjusted for social support.ConclusionsThe findings of the current study are consistent with previous research and throws light on the dire need for interventions to address mental health needs of Pakistani elderly.Implications for improving the mental health status of elderly are also presented.