Glucose‐oxidase (GOx)‐mediated starvation by consuming intracellular glucose has aroused extensive exploration as an advanced approach for tumor treatment. However, this reaction of catalytic oxidation by GOx is highly dependent on the on‐site oxygen content, and thus starvation therapy often suffers unexpected anticancer outcomes due to the intrinsic tumorous hypoxia. Herein, porous platinum nanospheres (pPts), incorporated with GOx molecules (PtGs), are synthesized to enable synergistic cancer therapy. In this system, GOx can effectively catalyze the oxidation of glucose to generate H2O2, while pPt triggers the decomposition of both endogenous and exogenous H2O2 to produce considerable content of O2 to facilitate the glucose consumption by GOx. Meanwhile, pPt induces remarkable content of intracellular reactive oxygen species (ROS) under an alternating electric field, leading to cellular oxidative stress injury and promotes apoptosis following the mechanism of electrodynamic therapy (EDT). In consequence, the PtG nanocomposite exhibits significant anticancer effect both in vitro and in vivo. This study has therefore demonstrated a fascinating therapeutic platform enabling oxygen‐inductive starvation/EDT synergistic strategy for effective tumor treatment.

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Recently, remarkable efforts have been made in developing wireless communication systems at ultrahigh data rates, with radio frequency (RF) carriers in the millimeter wave (30–300 GHz) and/or in the terahertz (THz, >300 GHz) bands. Converged technologies combining both the electronics and the photonics show great potential to provide feasible solutions with superior performance compared to conventional RF technologies. However, technical challenges remain to be overcome in order to support high data rates with considerably feasible wireless distances for practical applications, particularly in the THz region. In this work, we present an experimental demonstration of a single-channel THz radio-over-fiber (RoF) system operating at 350 GHz, achieving beyond 100 Gbit/s data rate over a 10-km fiber plus a >20-m wireless link, without using any THz amplifiers. This achievement is enabled by using an orthogonal frequency division multiplexing signal with a probabilistic-shaped 16-ary quadrature amplitude modulation format, a pair of highly directive Cassegrain antennas, and advanced digital signal processing techniques. This work pushes the THz RoF technology one step closer to ultrahigh-speed indoor wireless applications and serves as an essential segment of the converged fiber-wireless access networks in the beyond 5G era.

In this work the dependence of limiting current on gas pressure and temperature was measured to separate the oxygen transport resistance into its components: molecular diffusion resistance in the gas diffusion layer (GDL) and resistance in the catalyst layer (CL), which comprises Knudsen diffusion resistance and oxygen permeation resistance through ionomer. The effect of microporous layer (MPL) modification by laser perforation on the oxygen transport resistances was investigated. The resistance in CL contributed a significant portion, about one quarter, to the total oxygen transport resistance. A trend of decreasing CL resistance with increasing temperature was observed. This temperature effect was mainly attributable to the oxygen permeation in CL ionomer. The MPL modification had little influence on the total transport resistance as well as its individual component for the cells under dry operation, while the perforated MPL significantly reduced the transport resistance when water starts to condense in electrode. This finding indicated that the MPL plays important roles in the cathode water management.

Electrodynamic therapy (EDT) has emerged as an alternative stimuliresponsive approach for tumor treatment. The current understanding of its mechanism is that an electric field activates water dissociation on platinum nanoparticles (PtNPs) to produce toxic hydroxyl radicals. Nevertheless, the argument here remains that, if without direct contact with electrodes, the equipotential surfaces of PtNPs may hardly trigger electrocatalytic reactions and thus the induction of any radicals. Clearly, the limited understanding of EDT has considerably hindered its current and further explorations. Herein, the fundamental mechanism of EDT is revealed from the view of heterogeneous catalysis. First and foremost, the free chlorine generated during electrolysis is identified as the crucial reactant, which is not observed previously. Through experimental examinations and density functional theory (DFT) calculations, the fundamental reaction is confirmed to be the catalytic activation of HOCl by PtNPs, resulting in the production of oxygen anion radicals and the corrosion of PtNPs. Moreover, the cytotoxicity and intracellular abnormalities further verify the findings and provide new insight into its in vitro anti-cancer mechanism. This study not only assists in re-recognizing the nature of EDT, but also provides core knowledge in guiding its future investigations in catalytic medicine and medical technologies.