In order to study the fractal characteristics of the pomegranate biotite schist under the effect of blasting loads, a one-dimensional SHPB impact test was carried out to test the dynamic compressive strength, damage morphology, fracture energy dissipation density, and other parameters of the rocks under different strain rates; besides, sieve tests were conducted to count the mass fractal characteristics of the crushed masses under different strain rates to calculate the fractal dimension of the crushed rock D . Finally, the relationships between fractal dimension and dynamic compressive strength, crushing characteristics, and energy dissipation characteristics were analysed. The results show that under different impact loads, the strain rate effect of the rock is significant and the dynamic compressive strength increases with the increasing strain rate, and they show a multiplicative power relationship. The higher the strain rate of the rock, the deeper the fragmentation and the higher the fractal dimension, and the fractal dimension and rock crushing energy density are multiplied by a power relationship. By performing the comparative analysis of the pomegranate biotite schist, a reasonable strain rate range of 78.75 s-1~82.51 s-1 and a reasonable crushing energy consumption density range of 0.78 J·cm-3~0.92 J·cm-3 were determined. This research provides a great reference for the analysis of dynamic crushing mechanism, crushing block size distribution, and crushing energy consumption of the roadway surrounding rock.
In order to effectively reduce the disturbance of the precrack blasting vibration on slope rock mass, except paying attention to the damping effect of the precrack, it is also necessary to optimize the blasting parameters and initiation mode of the precrack itself. Based on the blasting theory and empirical formula, the parameters of presplitting blasting such as the hole diameter, hole spacing, charge decoupling coefficient, and line charge density were determined, and field tests of conventional pre-splitting blasting and presplitting blasting with precise delay and hole-by-hole initiation were carried out on the west slope of Buzhaoba. Regression analysis was carried out on the vibration monitoring data, and the blasting vibration attenuation regularity of slope particles was obtained. By comparing the monitored vibration velocity of the two presplitting blasting tests and the forecast results of theoretical calculation, the average reduction rate of the conventional same row blasting vibration is 26.40%, while that of the hole-by-hole blasting vibration can reach 41.45% with a half hole rate of 80.7% and an irregularity of about 130 mm. Results show that the effect of precise delay initiation between preholes based on the digital electronic detonator is better than that of the simultaneous initiation of preholes. Therefore, it is suggested that the hole-by-hole presplitting blasting technology should be applied in the excavation of boundary slope and the treatment of high and steep slope.
In order to study the influence of pillar stopping blasting on the stability of cemented backfill, the dynamic impact test under low strain rate (61.1∼86.8 s−1) was conducted on cemented backfill with two kinds of strength using three-dimensional coupled static-dynamic SHPB equipment. At the same time, the strain rate effect of failure mode, dynamic strength factor, and energy transfer of backfill were analyzed. The results show that when the cemented backfill was loaded under different strain rates in the initial three-dimensional static pressure environment, the pore compaction process was no longer obvious but directly entered the elastic deformation stage. Within the range of strain rates, the extreme value of dynamic intensity factor (DIF) of CTB230 was 6.8, while the extreme value of dynamic intensity factor of CTB310 specimen did not appear within the range of strain rates due to the improvement of the internal cementation force between particles. The fracture surfaces of specimens were perpendicular to the direction of load, and the failure mode was mainly the axial tensile failure, and the fracture surfaces were mostly close to the loading end. According to energy calculation, reflected energy accounts for 80.4%∼86.6% of incident energy; dissipated energy, 5.5%∼14.3%; transmitted energy, 5.3%∼7.9%.
Cardiovascular diseases (CVDs) are the leading causes of human death worldwide. Genetic variants serve as the major risk factor for CVDs, with limited therapeutic interventions in clinical practice. The recent surge of genome editing technologies offers the hope to correct genetic variants and to cure genetic diseases. Among the diverse genome editing tools, adenine base editors (ABEs) exhibit high efficiency, high specificity, and low off-target effects, successfully entering a clinical trial and demonstrating the tremendous potential to transform modern cardiovascular therapy. In this review, we summarize the basic knowledge about ABE, showcase three hallmark studies using ABE to ameliorate or treat CVDs in experimental animals, and lastly discuss about the key technical concerns that should be addressed to achieve the full potential of ABEs in the future.
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