Developing efficient methods for preparing the privileged chiral ligands is an important endeavor in synthetic chemistry. Herein, we develop an effective, modular method for synthesis of tertiary amine-derived C2-symmetric chiral...

Strategies to single-step edit the core skeleton of structurally complex compounds still remain highly desirable but challenging. Herein an unexpected discovery to access natural product dehydrocostus lactone/parthenolide-inspired bispiro[oxindole-oxazinane] hybrids enabled...

Here, we demonstrate that the first example of natural product harmaline or its derivatives serving as useful N-C synthons in formal [3+2] cycloadditions with isothiocyanates for the construction of a...

Herein, a previously unreported Fischer’s base reactants serving as useful 2C building blocks in (3+2) cycloaddition reactions to build a library of bispiro[Fischer base-oxindole] hybrids is described. These structurally intriguing...

Herein a previously unreported trimethylindolenines serving as useful C-N synthons in [3+2] cycloaddition reactions of donor-acceptor 3-isothiocyanato oxindoles to build a library of spiro[oxindole-thioxoimidazolidine-indoline] hybrids is described. A wide range...