To achieve accurate segmentation of thyroid nodule ultrasound images, obtain information on the physiological parameters of the lesion area and guide the clinical formulation of individualized treatment plan, an improved network based on the U2‐Net model is proposed in this paper. Thyroid images of 264 patients and 215 healthy volunteers at the First Hospital of Shanxi Medical University from February 2016 to June 2022 are studied, and the digital database thyroid image (DDTI) data set is proposed for data expansion. The experimental results show that the Dice coefficient on the test set was 80.58%, and the mean intersection over union was 81.21%. The improved U2‐Net model has the best segmentation accuracy compared with similar models, realizes the automatic segmentation of thyroid nodules, provides help for manual segmentation, and has good application prospects and clinical value.
Background: Sorafenib is an effective treatment for radioiodine (RAI)-refractory differentiated thyroid carcinoma (DTC), but adverse events limit its use. We investigated the synergistic anticancer effects of silencing lncRNA-PVT1 and sorafenib in papillary thyroid carcinoma (PTC) cell lines.Methods: B-CPAP, TPC-1, IHH-4 and K1 papillary thyroid carcinoma cell lines were used. A small interfering RNA (siRNA)-PVT1 sequence was used to silence lncRNA-PVT1 expression. Cell proliferation, migration and invasion, apoptosis, and cell cycle assays were conducted following PVT1 silencing and/or sorafenib treatment.Results: Sorafenib had inhibitory effects on PTC cell lines, and the cell survival rate decreased with increasing concentrations. LncRNA-PVT1 knockdown combined with 9 μM sorafenib in B-CPAP cells and 13 μM sorafenib in TPC-1 cells synergistically reduced the number of colonies formed, reduced invasion and migration, and promoted cell apoptosis.Conclusion: Sorafenib had inhibitory effects on TPC-1, B-CPAP, IHH4, and K1 cells, and lncRNA-PVT1 knockdown combined with sorafenib in B-CPAP and TPC-1 cells synergistically reduced the number of colonies formed, reduced invasion and migration, and promoted cell apoptosis.
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