Background Targeted metabolomics was utilized in case studies of non-small cell lung cancer (NSCLC) to develop and test metabolite classifiers in serum as potential biomarkers for new lung cancer diagnostic strategies, cancer staging, and subtype determination in the Chinese population. Methods A total of 77 samples, including 45 NSCLC patients from stage I to IV, and 32 healthy controls were included in this study. After serum extraction, metabolic assays based on a wide range of targeted metabolome technologies and the UPLC-MS-MS detection platform were performed to detect metabolites in them. Custom database and multivariate statistical analysis were utilized to evaluate the difference of metabolome between different arms. Results A total of 296 metabolites were detected in all samples, of which 81 were found differentially expressed among lung cancer patients and controls. While the principal component analysis indicated that the metabolome analysis is clearly powerful in differentiating lung cancer patients from normal controls, no significant differences in the serum metabolites between different lung cancer stages or between adenocarcinoma and squamous cell carcinoma were observed. Conclusions This study showed the power of the novel UPLC-MS/MS platform in serum metabolic profiling for the detection of NSCLC, which might provide new potential tumor biomarkers and can accelerate the development of new diagnostic strategies in NSCLC.
Both wall movement mode and soil arching are important to the active earth pressure on rigid retaining wall, but the method of active earth pressure under wall movement modes considering arching effects is yet to be studied. A series of minor principal stress trajectories described by the power function with the exponent b is assumed to analyze the soil arching effect using the equivalent friction coefficient between adjacent soil layers. The horizontal Winkler elastic foundation beam model induced by wall movement modes is presented. Then based on the trajectories and wall movement modes the horizontal flat-element method of active earth pressure on rigid retaining wall is improved and verified.The active earth pressures on the retaining wall under translation (T), rotation about top (RT) mode and rotation about bottom (RB) mode calculated by the improved method are in a better agreement with the experimental results than other analytical studies. The application point of the resultant active earth pressure on retaining wall increases from 0.25 H to 0.49 H with varies of wall movement modes considering soil arching effect. The larger equivalent friction coefficient is, the more notable soil arching effect is. The most notable soil arching effect is described by the approximate linear minor principal stress trajectory whose power function with exponent of b approaches zero from positive direction. The active earth pressure on retaining wall under RT mode considering the most notable soil arching effect is simplified and suggested for the engineering practice.
Underground salt caverns are widely used in large-scale energy storage, such as natural gas, compressed air, oil, and hydrogen. In order to quickly build large-scale natural gas reserves, an unusual building method was established. The method involves using the existing salt caverns left over from solution mining of salt to build energy storages. In 2007, it was first applied to Jintan Natural Gas Storage of China. Based on this successful project, several existing salt caverns were screened to build energy storages in China. Engineering experience indicates that the key to successful reusing is how to select the most suitable of the numerous available caverns and confirm it. This paper summarizes and reviews relevant theories and testing methods, including: (1) the primary selection principle for using existing salt caverns to build energy storage, (2) the testing method and evaluation theory of tightness of the existing salt cavern, and (3) the typical project case of using the existing salt caverns to build energy storage in China. From the practical application results, the selection principle proposed in this paper can quickly screen available existing salt caverns with energy storage potential, and the brine injection method can effectively evaluate their tightness. It provides a technical roadmap for the subsequent implementation of existing salt cavern utilization projects on a large scale.
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