Background: It has been proved that lncRNAs could function as CeRNA for miRNAs in tumor growth and metastasis for cervical cancer. This paper aims to identify the role of LINC02381 in cervical cancer cells. Materials and Methods: RT-qPCR was utilized to measure the expression levels of LINC02381 in cervical cancer tissues and cells. MTT, colony formation assay, transwell assay, RT-qPCR, and Western blotting were performed to investigate the roles of LINC02381 in cervical cancer cells. RegRNA 2.0 was used to predict the miRNA-binding sites of LINC02381. Luciferase reporter assay and RT-qPCR were employed to confirm the sponging effect between miR-133b and LINC02381. Results: This study showed that LINC02381 was up-regulated in cervical cancer cells and acted as an oncogene in the development of cervical cancer. LINC02381 promoted cell viability and metastasis via sponging miR-133b. Moreover, miR-133b could target its downstream mediator of RhoA and inhibit its expression. Conclusion: Overall, our results indicated that LINC02381 functions as an oncogene in cervical cancer and could serve as a novel target for cervical cancer therapies in the future.

No abstract

No abstract

Recently, the clamp double sub-module (CDSM) topology with its DC fault clearance ability has become more attractive for use in the modular multilevel converter (MMC)-based high-voltage DC transmission systems. However, the capacitor voltage imbalance caused by the discreteness of the device parameters during the uncontrolled pre-charging process seriously affects the system's safe start-up. To solve this problem, this study provides a novel CDSM-MMC capacitor static voltage balance method. Since the power supplies obtaining energy from the CDSM capacitors greatly influence the static voltage balance, the power supply input current is chosen as the control variable. On the basis of the control signals generated by the voltage balance algorithm, the control of the CDSM power supply input currents makes the arm energy be an average distribution in the CDSM capacitors. This method can replace the capacitor equalising resistors of CDSM to achieve capacitor voltage balance and can reduce the CDSM-MMC's losses. The method requires no additional circuits, and the control strategy is simple. Moreover, the method can apply to the static voltage balance control of other SM topologies with two capacitors. An arm cascaded with two CDSMs is tested and the results show the effectiveness of the proposed method.

No abstract

No abstract