This study constructs three regulatory networks of microRNAs (miRNAs) and genes in breast cancer (BC), and the abnormally expressed network may be the fault graph of BC's canceration, which helps us identify pathogenesis of BC. Scientists have identified genes and miRNAs as decisive biological factors in progression of BC. Insufficiently, research data of genes and miRNAs is unorganized and scattered, which made regulatory mechanism of BC still indeterminate. In the current study, we didn't only investigate one or several elements (miRNAs, TFs, target genes and host genes) associated with morbidity of BC. Instead, we systematically studied regulatory interactions among the whole elements relevant to BC and important regulatory pathways during BC's canceration. Then three regulatory networks (including the abnormally expressed network, related network and global network) are hierarchically constructed at three levels, aiming at analyzing significant miRNA-gene signaling pathways at the macroscopic level. Results shows the abnormally expressed network contains substantial faulty regulations between miRNAs and genes when BC occurs, and it may be underlying fault graph of BC's canceration. Significantly, if medical measure can be taken to correct each faulty regualtion to normal regulation, thus each genes and miRNAs will return to its normal expression level, and canceration of BC may be prevented and not occur. Furthermore, regulatory networks contain massive self-adaption feedbacks, which helps to understand the regulatory mechanism of BC. In conslusion, these networks, especially the abnormally expressed network, offers a systematical explanation about BC's pathogenesis, which may aid future research and therapy of BC. Keywords: Breast cancer, MicroRNA, Transcription factor, Abnormally expressed, Network ÖZET Meme Kanserinde MicroRNAs, Transkripsiyon Faktörleri, Hedef Genler ve Host Genlerin Ağ AnaliziBu çalışmada meme kanseri patogenezinini aydınlatabileceğini düşündüğümüz üç düzenleyici ağın microRNA (miRNA), genlerin analizi yapılmıştır. Bilim adamları meme kanserinde progresyon için belirleyici olan genleri ve miRNA'ları tespit etmişlerdir. Ancak meme kanserinin regülasyonunda gen ve miRNA'lar hakkında veriler yetersizdir. Bu çalışmada biz sadece bir iki gen veya miRNA çalışmadık.Biz meme kanserinde ve karsinogenezinde önemli düzenleyici etkileşimleri sistematik olarak çalıştık. Sonrasında üç düzenleyici (anormal olarak eksprese edilmiş ağlar dahil, ilgili yerel ağlar ve global ağlar) ağı hiyerarşik olarak üç seviyede inceledik, önemli miRNA-gen signal yolağını makroskopik düzeyde analiz ettik. Sonuçlarda anormal olarak eksprese edilmiş ağlar miRNA ve genlerin hatalı regül-asyonu sonucu meme kanseri ve karsinogenezinde rol aldığını saptadık. Eğer etkin tıbbi tedavilerle herbir gen ve miRNA seviyeleri normal seviyelere getirilebilirse meme kanseri oluşumu önlenebilir. Bununda ötesinde, meme kanserindeki düzenleyici ağları anlamayı kolaylaştıran, düzenleyici ağlar kendi kendini ayarlama konusunda geri ...
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