Accumulating evidence has indicated that oxidative stress (OS) is associated with the development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely unknown. Normally, OS occurs when the body receives any danger signal—from either an internal or external source—and further induces DNA oxidative damage and abnormal protein expression, placing the body into a state of vulnerability to the development of various diseases such as cancer. There are many factors involved in liver carcinogenesis, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, alcohol abuse, and nonalcoholic fatty liver disease (NAFLD). The relationship between OS and HCC has recently been attracting increasing attention. Therefore, elucidation of the impact of OS on the development of liver carcinogenesis is very important for the prevention and treatment of liver cancer. This review focuses mainly on the relationship between OS and the development of HCC from the perspective of cellular and molecular mechanisms and the etiology and therapeutic targets of HCC.

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The aim of this study was to explore the protective effects of ulinastatin (urinary trypsin inhibitor, UTI) on liver ischemia-reperfusion injury (IRI) and graft survival. We employed mouse liver cold IRI and orthotopic liver transplantation (OLTx) models. UTI was added to lactated Ringer's (LR) solution for liver perfusion and preservation in vitro or combined with UTI injection intraperitoneally to the liver graft recipient. Our results indicated that UTI supplementation protected the liver from cold IRI in a dose-dependent manner and prolonged liver graft survival from extended cold preserved liver donors significantly. The underlying mechanism of UTI on liver IRI may be mediated by inhibition of proinflammatory cytokine release, increasing the expression of the antiapoptotic gene Bcl-2 and decreasing the expression of the proapoptosis genes of Caspase-3 and Bax, and further protects hepatocytes from apoptotic death and improves liver function.

Background:We aimed to understand the curative effect of liposuction curettage (LC) in the treatment of bromhidrosis.Methods:Relevant studies published before January 2017were searched from the PubMed, Embase, Cochrane Library, Wanfang, VIP, and China National Knowledge Infrastructure databases. Parameters including recurrence, complications, complete response, and overall response were assessed. Meta-analysis was performed using the R 3.12 statistical package. Odds ratio (OR) and 95% confidence interval (95% CI) were used for dichotomous data. Heterogeneity was assessed using Cochran's Q-statistic and I2 test. In addition, Egger's test was conducted to detect publication bias.Results:Ten studies with a total of 1124 participants (545 cases and 579 controls) were included. There was no statistical difference in recurrence (OR = 1.19, 95% CI: 0.51–2.74), complete response (OR = 0.66, 95% CI: 0.25–1.74), or overall response (OR = 0.63, 95% CI: 0.21–1.87) between the case and control groups. The incidence of complications in the case group was lower than that in the control group (OR = 0.24, 95% CI: 0.08–0.67) and open excision group (OR = 0.11, 95% CI: 0.07–0.19). Publication bias existed for the recurrence index in the open excision group (t = 3.3979, P = .04), but no publication bias was found in other subgroups, indicating stable results.Conclusions:LC, which has fewer complications, can be considered the primary choice in the treatment of patients with bromhidrosis compared with other surgical procedures.

Allograft functional failure due to acute or chronic rejection has long been a major concern in the area of solid organ transplantation for decades. As critical component of innate immune system, the macrophages are unlikely to be exclusive for driving acute or chronic sterile inflammation against allografts. Traditionally, macrophages are classified into two types, M1 and M2 like macrophages, based on their functions. M1 macrophages are involved in acute rejection for triggering sterile inflammation thus lead to tissue damage and poor allograft survival, while M2 macrophages represent contradictory features, playing pivotal roles in both anti-inflammation and development of graft fibrosis and resulting in chronic rejection. Macrophages also contribute to allograft vasculopathy, but the phenotypes remain to be identified. Moreover, increasing evidences are challenging traditional identification and classification of macrophage in various diseases. Better understanding the role of macrophage in chronic rejection is fundamental to developing innovative strategies for preventing late graft loss. In this review, we will update the recent progress in our understanding of diversity of macrophage-dominated innate immune response, and reveal the roles of M2 macrophages in chronic allograft rejection as well.

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The residue and dissipation of florasulam in wheat and soil were determined by high performance liquid chromatography-tandem mass spectrometry. The dissipation half-lives for florasulam in soil were 0.66 days in Zhejiang and 0.64 days in Hebei. In wheat plant, half-lives of florasulam were 5.16 days in Zhejiang and 2.07 days in Hebei. The residues of florasulam in wheat grain, wheat straw and soil were below the detection limit (i.e., 0.01 mg/kg, the maximum residue level of florasulam). These results would be helpful in setting MRL guidance of florasulam in wheat in China.

With the massive consumption of fossil energy, the traditional power system can no longer meet the high-quality development of the economy and society and the strict requirements of the ecological environment. The whole society urgently needs to build a new generation of power system to achieve the healthy development of the economy and society under increasingly strict constraints. For the new generation of power systems, the mainstream direction is that they should promote the deep replacement of fossil energy with electric energy in the energy consumption link, and increase the proportion of electricity in the final energy consumption and clean power generation. In addition, it should also include the informatization, intelligence and digitization of the power and even energy systems, and realize the iterative optimization of the whole system with faster communication and faster computer processing technology. In this paper, Dematel analysis method was used to identify and screen the construction elements of the new generation power system. And the role of each element in the construction process was analyzed, thus the key areas in the construction of the new generation power system were clarified.