Background
Photodynamic therapy (PDT) can be performed as palliative therapy for cholangiocarcinoma, while there is currently insufficient evidence for the efficacy. The aim of this study was to explore the clinical efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP)- or percutaneous transhepatic cholangioscopy (PTCS)-directed PDT combined with stent placement for unresectable hilar cholangiocarcinoma.
Methods
A retrospective analysis was conducted on 62 patients with unresectable hilar cholangiocarcinoma. Thirty patients received PDT using hematoporphyrin combined with biliary stent placement (PDT+stent group), including 22 receiving ERCP-directed PDT and 8 receiving PTCS-directed PDT. Survival time, quality of life, and postoperative adverse events were compared to 32 patients receiving biliary stent placement alone (Stent-only group).
Results
After 42 months of follow-up, median survival time was significantly longer in the PDT+stent group than the Stent-only group (14.2 vs. 9.8 months, P = 0.003). In the PDT+stent group, the median survival time was longer in the 6 patients with recurrence after surgical resection than the 24 patients without prior surgical resection (20.0 vs. 13.0 months, P = 0.017). The QOL total scores was significantly higher in the PDT+stent group than the Stent-only group at postoperative 6, 9, and 12 months (P<0.05). There was no significant difference in the incidence of postoperative adverse events between the two groups (24 [38.7%] vs. 20 [29.0%], P = 0.239).
Conclusion
ERCP- or PTCS-directed PDT + stent placement can prolong the survival of patients with unresectable hilar cholangiocarcinoma, especially those with recurrence and improve quality of life without increasing adverse events.
<p><strong>Objective:</strong> Exploring the treatment of combined posterior lateral approach with open reduction and internal fixation for the treatment of combined fractures of the ankle on the treatment of tibial plateau fractures with Schatzker types II and III. <strong>Method: </strong>Between April 2012 and March 2015, 16 cases of Schatkzer types II and III tibial plateau fractures were treated with T or L type limited contact dynamic compression plate (LC-DCP). <strong>Results: </strong>All 16 cases were followed-up for 12 to 36 months, with an average of 18.3 months. According to the Merchant score, 10 cases were excellent, good in 4 cases, and in 2 cases, the excellent and good rating was 87.5%. <strong>Conclusion:</strong> After treatment, anatomical reduction and stability of the posterior condyle was emphasized, and there were early functional usage and recovery of the joint functions. At the same time, the external side of the incision can be used to restore the external and rear sides to avoid replacement of the body position and improve the operation efficiency.</p>
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