Camptothecin (CPT) is a potent chemotherapeutic agent for various cancers, but the broader application of CPT is still hindered by its poor bioavailability and systemic toxicity. Here, a prodrug that releases CPT in response to glutathione (GSH), which is commonly overexpressed by cancer cells is reported. Through assembling with PEGylated lipids, the prodrug is incorporated within as‐assembled nanoparticles, affording CPT with a prolonged half‐life in blood circulation, enhanced tumor targetingability, and improved therapeutic efficacy. Furthermore, such prodrug nanoparticles can also promote dendritic cell maturation and tumor infiltration of CD8
+
T cells, providing a novel strategy to improve the therapeutic efficacy of CPT.
superconducting tokamak in the Institute of Plasma Physics of the Chinese Academy of Sciences is an experimental device for fusion research in China. The main task of the data acquisition system of HT-7 is to acquire, store, analyze and index the data. The volume of the data is nearly up to hundreds of million bytes. Besides the hardware and software support, a great capacity of data storage, process and transfer is a more important problem. To deal with this problem, the key technology is data compression algorithm. In the paper, the data format in HT-7 is introduced first, then the data compression algorithm, LZO, being a kind of portable lossless data compression algorithm with ANSI C, is analyzed. This compression algorithm, which fits well with the data acquisition and distribution in the nuclear fusion experiment, offers a pretty fast compression and extremely fast decompression. At last the performance evaluation of LZO application in HT-7 is given.
Cavity-filling is a common phenomenon whereby a fluid fills all or part of a cavity, displacing another immiscible fluid. In this study, we experimentally and theoretically investigate the effects of the cavity aspect ratio, channel width, tilting angle of the cavity leading wall, and inlet flow rate on the morphology of the water-air interface and the filling fraction of various cavities. Considering the influencing factors, we derive two formulas for predicting the filling fraction, and verify these expressions against experimental results. The findings of this study provide theoretical guidance for applications related to pressure-driven filling of cavity structures.
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