The front cover artwork is provided by groups of Hong Yang and Gang Han at the College of Chemistry and Materials Science at Shanghai Normal University (China) and the Department of Biochemistry and Molecular Pharmacology at UMass Medical School (United States). The image shows a purple sphere transducer linked with a non‐active prodrug by photosensitive linkers. Upon irradiation with long‐wavelength light, the transducer converts the incident light to short wavelength emission to cleave the photocleavable linkers and trigger drug release. Read the full text of the Minireview, in which such developments in light‐activated prodrugs for biomedical application are reviewed, athttps://doi.org/10.1002/cptc.201800147.
A novel family of ruthenium nitrosyl complexes [Ru(bpy)(C∧N)(MeCN)NO](PF6)2 (2a–2e, bpy = 2,2′-bipyridine, HC∧N = 2-phenylpyridine and its derivatives) has been prepared by reacting cyclometalated ruthenium complexes [Ru(bpy)2(C∧N)][PF6] (1a–1e) with NO+, which were comprehensively characterized by mass, IR, NMR, and UV–vis spectra as well as the single-crystal X-ray structure determinations. Herein, the coordination geometry of Ru atoms in 2a–2e is a distorted octahedron and {RuII–NO+}6 is present in these complexes. Theoretical calculations suggest that the reactions involving dissociation of one bipyridine and coordination with NO+ proceed spontaneously (ΔG < 0) and the transformation from 1a–1e to the intermediates is dominated by substituents (ΔG RI varies from −1.19 to −1.53 eV), which influence the binding energy between Ru(II) and NO+ in complexes 2a–2e (−89.42 to −101.17 kcal/mol) and thus control the photorelease of NO on a certain scale. The weak absorption bands in the visible region could be attributed to the contribution of dπ(RuII) → π*(NO+), which were enhanced greatly under light, indicating the possible release of NO. The photoinduced NO, as well as singlet oxygen (1O2), was then confirmed by EPR spectra, and the amount of NO released from 2a–2e was estimated via Griess reagent assay. The cytotoxicity of these complexes with or without visible light irradiation was also investigated using an MTT assay.
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