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In order to solve the difficulties in the construction design of pile foundation and cushion cap of bridge substructure caused by marsh geology and tidal environment abroad, according to the European standard EN 1997, a new form of integrated design of retaining wall and cofferdam construction is creatively proposed. The whole process of structural design is studied in detail from the aspects of structural selection, determination of load and load partial coefficient, checking calculation of component design details. Taking the Brunei project as a case, the results show that the integrated design method of retaining wall and cofferdam construction can effectively improve the performance of the pile foundation of the beam substructure, meet the requirements of European standard EN 1997, and provide technical reserves for the construction of similar bridge projects abroad.