Background Intracranial atherosclerotic stroke (ICAS) is strongly associated with single and multiple infarctions. The present study aimed to assess the associations of imaging-based lesion category and intracranial atherosclerosis burden (ICASB) with ischemic stroke (IS), and to determine whether multiple infarctions may be related to increased prevalence of ICASB. Methods In this study, 2864 consecutive cases from 22 Chinese hospitals who had acute cerebral ischemia < 7 days after symptom onset were included. After magnetic resonance angiography, the patients were categorized into three groups, with scores of < 4, 4–7 and > 7, respectively, according to the degree of IS reflected by ICASB, and also divided into single and multiple infarction groups taking into consideration the number of acute infarction-related lesions. Results Reduced NIHSS score at patient admission and complete circle of Willis were closely associated with single infarction. However, patients with multiple infarctions had higher ICASB compared with the single infarction group, particularly in the ICASB4-7 and > 7 subgroups (P < 0.0002). Patients with multiple infarctions showed prolonged hospital stay (p < 0.0033) and increased brain damage or ischemic stroke (IS) recurrence within 1 year (p < 0.0008). In multivariate analysis, complete circle of Willis (HR = 2.56, 95%CI 1.16–5.66; P = 0.0199) and family history of stroke (HR = 2.07, 95%CI 1.054–4.071; P = 0.034) were independent predictors of multiple infarctions, unlike elevated ICASB (ICASB4-7 group, p = 0.23; ICASB > 7group, p = 0.24) Conclusions Patients with multiple infarctions have significantly elevated ICASB, and show increase brain damage or IS recurrence within 1 year. High ICASB is not an independent predictor of multiple infarctions.
To analyze the correlation between the occurrence of vertebral artery ostium stenosis (VAOS) and the severity of osteoporosis in elderly patients with atherosclerosis (AS), and disclose the physiopathologic mechanism of the correlation between VAOS and osteoporosis. 120 patients were divided into two groups. The baseline data of both groups were collected. The biochemical indicators of patients in both groups were collected. The EpiData database was established to enter all the data into the database for statistical analysis. There were significant differences in the incidence of dyslipidemia among risk factors of cardia-cerebrovascular disease (P<0.05). LDL-C, Apoa and Apob were significantly lower than the control group (P<0.05). BMD, T-value and Ca in the observation group were significantly lower than the control group, while BALP and serum phosphorus in the observation group were significantly higher than the control group (P<0.05). The more severe the VAOS stenosis, the higher the incidence of osteoporosis, and there was a statistical difference in the risk of osteoporosis among different VAOS stenosis degrees (P<0.05). Apolipoprotein A, B and LDL-C in blood lipids are important factors affecting the development of bone and artery diseases. There is a significant correlation between VAOS and the severity of osteoporosis. The pathological calcification process of VAOS has many similarities with the process of bone metabolism and osteogenesis, and shows preventable and reversible physiological characteristics.
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