Primary hyperoxaluria type I (PH1), the most severe form of primary hyperoxalurias, is a liver disease of the metabolic defect in glyoxylate detoxification that can be corrected by liver transplantation. A 21-year-old man presented to our center after 4 months of regular hemodialysis for kidney failure caused by nephrolithiasis. A diagnosis of PH1 was confirmed by mutations of the AGXT gene. Left lateral sectionectomy of the native liver was performed; and auxiliary partial orthotopic liver transplantation (APOLT) and kidney transplantation were carried out synchronously using a living donor. After transplantation, the patient's plasma oxalate and creatinine levels substantially decreased and the patient recovered well with good dual grafts function. APOLT and kidney transplantation can compensate the liver deficient in liver enzyme production and aid the renal elimination of oxalate, thus serving as an effective treatment option for patients with PH1. In conclusion, left lateral sectionectomy of the native liver and combined living-related liver–kidney transplantation can be a surgical option for PH1.
Orthotopic rat liver transplantation (OLT) is a complex procedure extensively applicable to basic science, myriad complications can occur, incision-related self-biting has not been reported after liver transplantation. For the project of tolerance induction through stem cells, OLT was performed from inbred Sprague Dawley (SD) rat to SD (control group, n = 9), SD to Lewis (chronic rejection, n = 11), and OLT from Lewis allograft to Brown Norway (BN) rats (acute rejection, n = 63), the acute rejection group was sub-grouped into the transverse incision group(n = 26) and midline group(n = 37), Cyclosporine A was injected at 2mg/kg into the rejection groups once daily for 14 days, lidocaine cream alone or with naloxone was used for pain-relieving. The recipient survival and wound status were the primary endpoint of this study. For SD→SD, 30-day survival rate was 88.9%, no self-biting behavior occurred; for SD→Lewis, 30-day survival rate was 54.5%, the degree II of self-biting occurred in 2 cases. For Lewis→BN with transverse incision, 30-day survival rate was 51.8%, severe self-biting occurred in 16 cases in 8–27 days and 5 more cases over 30 days, which caused death or euthanasia, the degree 2 of biting occurred in 2 cases. For Lewis→BN with midline incision, 30-day survival rate was 86.0%, no severe self-biting occurred, mild self-biting in 2 cases. There was difference in the biting–related survival between two sub-groups (p = 0.003). In conclusion, incision-related self-biting behavior is species-specific for rats, the transverse incision is the pain-causing reason; the midline one is effective to avert occurrences.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.