We
have presented a simple and new method for the divergent assembly
of furoxans and isoxazoles in which the [2 + 1 + 1 + 1] annulation
reaction of sulfoxonium ylides is reported for the first time. When
the reaction was performed using tBuONO as the nitrogen
source without metal catalyst, the desired furoxans were obtained
in decent yields with wide substrate scope. Isoxazoles bearing three
carbonyl groups were achieved when the reaction was conducted using
Cu(TFA)2 as catalyst.
A direct and single‐step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid‐promoted [3+3] annulation between 3‐ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope.magnified image
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