The palladium-catalyzed cross-coupling reaction of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate in the presence of a copper mediator is reported. Under optimized conditions, all reactions worked well and provided difluoro-containing products in moderate to excellent yields.
A rapid, one-pot, catalyst-free approach to novel benzofuran-fused pyrido [4,3-d]pyrimidines with good antitumor activities via a cascade S N Ar/cyclization/condensation reaction through 2-(2-hydroxyphenyl) acetonitriles and 4,6-dichloropyrimidine-5-carbaldehyde was developed.
Copper-Mediated, Palladium-Catalyzed Cross-Coupling of 3-Iodochromones, Thiochromones, and Quinolones with Ethyl Bromodifluoroacetate. -The reactions of the compounds (If), (Va), and (VI) are incomplete. A mechanism is depicted. -(HAN, X.; YUE, Z.; ZHANG, X.; HE, Q.; YANG*, C.; J. Org. Chem. 78 (2013) 10, 4850-4856, http://dx.
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