Background Tyrosine protein tyrosine kinase binding protein (TYROBP) binds non-covalently to activated receptors on the surface of various immune cells, and mediates signal transduction and cellular activation. It is dysregulated in various malignancies, although little is known regarding its role in low-grade glioma. The aim of this study is to explore the clinicopathological significance, prognostic value and immune signature of TYROBP expression in low-grade glioma (LGG). Methods The differentially expressed genes (DEGs) between glioma samples and normal tissues were identified from two GEO microarray datasets using the limma package. The DEGs overlapping across both datasets were functionally annotated by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. STRING database was used to establish the protein-protein interaction (PPI) of the DEGs. The PPI network was visualized by Cytoscape and cytoHubba, and the core module and hub genes were identified. The expression profile of TYROBP and patient survival were validated in the Oncomine, GEPIA2 and CGGA databases. The correlation between TYROBP expression and the clinicopathologic characteristics were evaluated. Gene Set Enrichment Analysis (GSEA) and single-sample GSEA (ssGSEA) were performed by R based on the LGG data from TCGA. The TIMER2.0 database was used to determine the correlation between TYROBP expression and tumor immune infiltrating cells in the LGG patients. Univariate and multivariate Cox regression analyses were performed to determine the prognostic impact of clinicopathological factors via TCGA database. Results Sixty-two overlapping DEGs were identified in the 2 datasets, and were mainly enriched in the response to wounding, focal adhesion, GTPase activity and Parkinson disease pathways. TYROBP was identified through the PPI network and cytoHubba. TYROBP expression levels were significantly higher in the LGG tissues compared to the normal tissues, and was associated with worse prognosis and poor clinicopathological parameters. In addition, GSEA showed that TYROBP was positively correlated to neutrophil chemotaxis, macrophage activation, chemokine signaling pathway, JAK-STAT signaling pathway, and negatively associated with gamma aminobutyric acid signaling pathway, neurotransmitter transport, neuroactive ligand receptor intersection etc. TIMER2.0 and ssGSEA showed that TYROBP expression was significantly associated with the infiltration of neutrophils, macrophages, myeloid dendritic cells and monocytes. The infiltration of the M2 phenotype macrophages, cancer-associated fibroblasts and myeloid dendritic cells correlated to worse prognosis in LGG patients. Finally, multivariate analysis showed that elevated TYROBP expression is an independent risk factor for LGG. Conclusion TYROBP is dysregulated in LGG and correlates with immune infiltration. It is a potential therapeutic target and prognostic marker for LGG.

No abstract

No abstract

Feature selection tries to find a subset of feature from a larger feature pool and the selected subset can provide the same or even better performance compared with using the whole set. Feature selection is usually a critical preprocessing step for many machine-learning applications such as clustering and classification. In this paper, we focus on feature selection for supervised classification which targets at finding features that can best predict class labels. Traditional greedy search algorithms incrementally find features based on the relevance of candidate features and the class label. However, this may lead to suboptimal results when there are redundant features that may interfere with the selection. To solve this problem, we propose a subset selection algorithm that considers both the selected and remaining features' relevances with the label. The intuition is that features, which do not have better alternatives from the feature set, should be selected first. We formulate the selection problem as maximizing the dependency margin which is measured by the difference between the selected feature set performance and the remaining feature set performance. Extensive experiments on various data sets show the superiority of the proposed approach against traditional algorithms.

No abstract

No abstract

A novel local structure descriptor (LSD) for color image retrieval is proposed in this paper. Local structures are defined based on a similarity of edge orientation, and LSD is constructed using the underlying colors in local structures with similar edge direction. LSD can effectively combine color, texture and shape as a whole for image retrieval. LSH integrates the advantages of both statistical and structural texture description methods, and it possesses high indexing capability and low dimensionality. In addition, the proposed feature extraction algorithm does not need to train on a large scale training datasets, and it can extract local structure histogram based on LSD. The experimental results on the Corel image databases show that the descriptor has a better image retrieval performance than other descriptors.

Abstract:Restricted by technical and budget constraints, hyperspectral (HS) image which contains abundant spectral information generally has low spatial resolution. Fusion of hyperspectral and panchromatic (PAN) images can merge spectral information of the former and spatial information of the latter. In this paper, a new hyperspectral image fusion algorithm using structure tensor is proposed. An image enhancement approach is utilized to sharpen the spatial information of the PAN image, and the spatial details of the HS image is obtained by an adaptive weighted method. Since structure tensor represents structure and spatial information, a structure tensor is introduced to extract spatial details of the enhanced PAN image. Seeing that the HS and PAN images contain different and complementary spatial information for a same scene, a weighted fusion method is presented to integrate the extracted spatial information of the two images. To avoid artifacts at the boundaries, a guided filter is applied to the integrated spatial information image. The injection matrix is finally constructed to reduce spectral and spatial distortion, and the fused image is generated by injecting the complete spatial information. Comparative analyses validate the proposed method outperforms the state-of-art fusion methods, and provides more spatial details while preserving the spectral information.