The development of wound dressings with combined antibacterial activities and pro-healing functions has always been an intractable medical task for treating bacterial wound infection. Herein, a novel injectable hybrid hydrogel dressing is developed, which is doped with nitric oxide (NO) donor (N,N'-di-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine, BNN6) loaded two-dimensional polydopamine nanosheets (PDA NS). The hydrogel matrix is in situ formed through dynamic Schiff base crosslinking between hydrazide-modified đ¸-polyglutamic acid (đ¸-PGA-ADH) and aldehyde-terminated Pluronic F127 (F127-CHO). Under 808 nm irradiation, the embedded PDA NS exhibits outstanding photothermal transform properties (56.1%) and on-demand NO release. The combination of photothermal and NO gas therapy with a synergistic antibacterial effect works on both Escherichia coli and Staphylococcus aureus in vitro. Furthermore, a full-thickness skin defect model also demonstrates that the hybrid hydrogel shows outstanding antibacterial properties and effectively accelerates the wound healing process. Overall, this study provides a facile and promising method for the fabrication of PDA NS based multifunctional hydrogel dressing for the application of infectious skin wound healing.
Various nanotechnologies have been extensively developed to prepare nanoparticles with different features for satisfying the requirements of diverse fields, but the current achievements are confined to different material systems for the limited acquisition with desirable properties. Here, we demonstrated a flexible strategy based on the broad selectivity of amines in the condensation of green tea polyphenol-EGCG (epigallocatechin gallate), formaldehyde, and amines for the rational design and preparation of versatile nanomaterials. With EGCG as the sole material system and amines (RâNH 2 ) of various functional R groups as the selectable modules, the modular assembly of polyphenolactivated condensation was straightforward and completed in one step, giving rise to different polyphenolic nanoparticles variable in surface chemistry (âamine, âaldehyde, and âcarboxyl), shapes (sphere, dumbbell, walnut), internal structures (solid, hollow, and porous), stimuli responsiveness (-s-s-), and fluorescence. The flexibility of the polyphenolic condensation for versatile nanoparticles was further demonstrated by the incorporation of amino-containing anticancer or antibacterial drugs into polyphenolic nanoparticles as nanodrugs. The present study totally involved the use of 13 different amines to synthesize 18 different nanoparticles, not only convincingly specifying the enormous value of the polyphenolic condensation as platform for modular assembly of versatile nanoparticles but also revolutionizing the current strategies and methodologies for encapsulated applications of tea polyphenols.
Finding suitable electrode materials for alkaliâmetalâion storage is vital to the nextâgeneration energyâstorage technologies. Polyantimonic acid (PAA, H2Sb2O6â¡ânH2O), having pentavalent antimony species and an interconnected tunnelâlike pyrochlore crystal framework, is a promising highâcapacity energyâstorage material. Fabricating electrochemically reversible PAA electrode materials for alkaliâmetalâion storage is a challenge and has never been reported due to the extremely poor intrinsic electronic conductivity of PAA associated with the highest oxidation state Sb(V). Combining nanostructure engineering with a conductiveânetwork construction strategy, here is reported a facile oneâpot synthesis protocol for crafting uniform internalâvoidâcontaining PAA nanoâoctahedra in a composite with nitrogenâdoped reduced graphene oxide nanosheets (PAAâNâRGO), and for the first time, realizing the reversible storage of both Li+ and K+ ions in PAAâNâRGO. Such an architecture, as validated by theoretical calculations and ex/in situ experiments, not only fully takes advantage of the largeâsized tunnel transport pathways (0.37 nm2) of PAA for fast solidâphase ionic diffusion but also leads to exponentially increased electrical conductivity (3.3 S cmâ1 in PAAâNâRGO vs 4.8 Ă 10â10 S cmâ1 in bareâPAA) and yields an insideâout buffer function for accommodating volume expansion. Compared to electrochemically irreversible bareâPAA, PAAâNâRGO manifests reversible conversionâalloying of Sb(V) toward fast and durable Li+â and K+âion storage.
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