With the continuous development of deep learning, the performance of the intelligent diagnosis system for ocular fundus diseases has been significantly improved, but during the system training process, problems like lack of fundus samples and uneven sample distribution (the number of disease samples is much smaller than the number of normal samples) have become increasingly prominent. In view of the previous issues, this paper proposes a method for generating fundus images based on “Combined GAN” (Com-GAN), which can generate both normal fundus images and fundus images with hard exudates, so that the sample distribution can be more even, while the fundus data are expanded. First, this paper uses existing images to train a Com-GAN, which consists of two subnetworks: im-WGAN and im-CGAN; then, it uses the trained model to generate fundus images, then performs qualitative and quantitative evaluation on the generated images, and adds the images to the original image set to expand the datasets; finally, based on this expanded training set, it trains the hard exudate detection system. The expanded datasets effectively improve the generalization ability of the system on the public datasets DIARETDB1 and e-ophtha EX, thereby verifying the effectiveness of the proposed method.
Active learning aims to select the most valuable unlabelled samples for annotation. In this paper, we propose a redundancy removal adversarial active learning (RRAAL) method based on norm online uncertainty indicator, which selects samples based on their distribution, uncertainty, and redundancy. RRAAL includes a representation generator, state discriminator, and redundancy removal module (RRM). The purpose of the representation generator is to learn the feature representation of a sample, and the state discriminator predicts the state of the feature vector after concatenation. We added a sample discriminator to the representation generator to improve the representation learning ability of the generator and designed a norm online uncertainty indicator (Norm-OUI) to provide a more accurate uncertainty score for the state discriminator. In addition, we designed an RRM based on a greedy algorithm to reduce the number of redundant samples in the labelled pool. The experimental results on four datasets show that the state discriminator, Norm-OUI, and RRM can improve the performance of RRAAL, and RRAAL outperforms the previous state-of-the-art active learning methods.
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