A straightforward synthesis of β-amino ketones has been realized by employing ketones and amides as the substrates via cobalt(III)-catalyzed and dimethyl sulfoxide-involved cross-coupling reaction. Experimental investigations revealed that the β-methylsulfide ketone species might be involved as the active intermediate. Diverse ketones (e. g. acetophenone and its derivatives, heteroaryl methyl ketones and dibenzoylmethane) and amides (e. g. aromatic, aliphaticand cyclicamides) with various substitution patterns were found to be applicable to this transformation, demonstrating a broad substrate scope and excellent functional group tolerance.
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