Objective: To assess the effectiveness of tele-monitored cardiac rehabilitation in patients who have undergone ablation for atrial fibrillation. Design: Single-centre, prospective, assessment-blinded, randomised controlled trial. Setting: Domiciliary rehabilitation with support from a tertiary care hospital. Subjects: One hundred patients who underwent ablation for atrial fibrillation were recruited. Interventions: Participants were randomly allocated to a 12-week standard rehabilitation treatment (control group) or a comprehensive, domiciliary, mobile application-guided and tele-monitored cardiac rehabilitation program (intervention group) in a 1:1 fashion. Main outcome measures: The primary endpoint was the improvement in VO2peak. The secondary outcomes included adherence, physical activity, beliefs related to cardiovascular disease and exercise self-efficacy. Results: Ninety-seven patients completed follow-up. The mean VO2peak increased significantly in both the intervention group ( n = 49) (baseline vs 12 weeks: 19.1 ± 4.7 vs 27.3 ± 5.6 ml/(min kg), P < 0.01) and the control group ( n = 48) (baseline vs 12 weeks: 18.7 ± 4.9 vs 22.9 ± 6.3 ml/(min kg), P < 0.01). The results of the between-group analysis of aerobic capacity were significantly in favour of the intervention group. During the 12-week program, patients in the intervention group exhibited better adherence than those in the control group. Moreover, self-reported physical activity improved more in the intervention group than in the control group, as did the beliefs related to cardiovascular disease and exercise self-efficacy (all P < 0.01). Conclusions: Our domiciliary, mobile application-guided and tele-monitored cardiac rehabilitation program could lead to a more significant improvements in physical fitness, adherence and health beliefs than standard cardiac rehabilitation in patients who have undergone ablation for atrial fibrillation.
An
interesting procedure for thioester synthesis via nickel-catalyzed
thiocarbonylation of arylboronic acid with sulfonyl chlorides as the
sulfur source has been explored. Using Mo(CO)6 as a solid
CO surrogate and reductant, a broad range of thioesters were obtained
in moderate to good yields with good functional group tolerance.
A nickel-catalyzed
one-pot carbonylation reaction of 2-bromobenzenesulfonyl
chlorides with alkynes for the synthesis of thiochromenones has been
established. Both terminal and internal alkynes were suitable substrates
in this carbonylative transformation, and a broad range of 2-mono-
and 2,3-disubstituted thiochromenone products were obtained in moderate
to good yields with quite high functional group compatibility. Notably,
this procedure presents the first example of nickel-catalyzed carbonylative
synthesis of thiochromenones with 2-bromobenzenesulfonyl chlorides
as a promising sulfur precursor.
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